Impact of critical process and formulation parameters affecting in‐process stability of lactate dehydrogenase during the secondary drying stage of lyophilization: A mini freeze dryer study
Authors:
- Jean‐Philippe ObertJOJean‐Philippe Obert
- Devendra S. KaloniaDKDevendra S. Kalonia
- Michael J. PikalMPMichael J. Pikal
- 1 September 2007
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 96 (9) , 2242-2250
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Investigation of Drying Stresses on Proteins during Lyophilization: Differentiation between Primary and Secondary-Drying Stresses on Lactate Dehydrogenase Using a Humidity Controlled Mini Freeze-DryerJournal of Pharmaceutical Sciences, 2007
- Measurement of the Kinetics of Protein Unfolding in Viscous Systems and Implications for Protein Stability in Freeze-DryingPharmaceutical Research, 2005
- Sustained In Vivo Activity of Recombinant Bovine Granulocyte Colony Stimulating Factor (rbG-CSF) Using HEPES BufferPharmaceutical Development and Technology, 2001
- Relation between Thermal Stabilizing Effect of Sucrose on LDH and Sucrose-LDH and Hydrogen Bond.JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 1998
- Surface-Induced Denaturation of Proteins during Freezing and its Inhibition by SurfactantsJournal of Pharmaceutical Sciences, 1996
- Interactions of Stabilizers with Proteins During Freezing and Drying1994
- Dehydration-induced conformational transitions in proteins and their inhibition by stabilizersBiophysical Journal, 1993
- An infrared spectroscopic study of the interactions of carbohydrates with dried proteinsBiochemistry, 1989
- The effect of freeze-drying on the quaternary structure of l-asparaginase from Erwinia carotovoraBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
- Enzyme Reaction Rates at Limited Water ActivitiesScience, 1967