Remodeling of the ryanodine receptor isoform 1 channel regulates the sweet and umami taste perception of Rattus norvegicus
Open Access
- 1 May 2023
- journal article
- research article
- Published by KEAI Publishing in Fundamental Research
- Vol. 3 (3) , 459-468
Abstract
• The stimuli contents in phosphoproteomic were set by their allosteric constants. • Sweet and umami stimuli cause the closed form of RyR1 channel. • A “metabolic clock” notion based on nutrient sensing is proposed.Keywords
Funding Information
- National Natural Science Foundation of China (31622042, 31671857, 31901782, 31901813, 31972198)
This publication has 55 references indexed in Scilit:
- Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste CellsPLOS ONE, 2013
- Umami taste in mice uses multiple receptors and transduction pathwaysThe Journal of Physiology, 2012
- Histidine-rich calcium binding protein: The new regulator of sarcoplasmic reticulum calcium cyclingJournal of Molecular and Cellular Cardiology, 2011
- Ryanodine receptors selectively contribute to the formation of taste‐evoked calcium signals in mouse taste cellsEuropean Journal of Neuroscience, 2010
- Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinasesProceedings of the National Academy of Sciences, 2010
- The cells and peripheral representation of sodium taste in miceNature, 2010
- Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1Cell Calcium, 2008
- Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacityProceedings of the National Academy of Sciences, 2008
- Mechanisms of specificity in protein phosphorylationNature Reviews Molecular Cell Biology, 2007
- Coding of Sweet, Bitter, and Umami TastesCell, 2003