Figure 4 from A Phase II Study of Berzosertib in Combination with Carboplatin Compared with Docetaxel with Carboplatin in Metastatic Castration-Resistant Prostate Cancer

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Abstract
A combined ATM-RS biomarker identifies the best responders. A and B, Representative images of ATM (A) and pKAP1 (B) staining by IHC in tumor biopsy samples. The scale bar corresponds to 100 μm. C, Box plot showing pKAP1 levels in samples stratified by ATM status. Horizontal red lines depict the cutoff used to classify samples as ATM-RS–positive or ATM-RS–negative. D and E, Kaplan–Meier plots for PFS in patients across both arms (D) and in Arm B only (E), stratified by the combined ATM-RS classification.