Wide-field spatial mapping of in vivo tattoo skin optical properties using modulated imaging

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Abstract
Modulated imaging is a new modality capable of wide-field, spatially resolved measurement of in vivo optical properties. Based on spatial light modulation, the method is inexpensive, non-contact, and allows spatial mapping of tissue absorption and reduced scattering coefficients at any wavelength between 450 and 1,100 nm. Currently, clinicians rely on qualitative visual inspection to guide parameter selection for laser-based tattoo removal. MI provides quantitative measurements of multi-colored tattooed skin which may help guide treatment and objectively assess response. We have measured the spatially varying optical properties of multi-colored tattooed skin over a 50 mm x 50 mm field of view at wavelengths ranging from 650 to 970 nm using MI. These measurements were compared to a similar field of view of non-tattooed skin from an adjacent area. We have determined the differentiated optical properties in vivo of multi-colored tattooed skin versus non-tattooed skin. MI provides spatially resolved quantitative information with potential for quantitative assessment of response to treatment and may provide guidance for laser tattoo removal in the future.
Funding Information
  • Laser Microbeam and Medical Program (LAMMP) NIH (P41 RR01192)
  • U.S. Air Force Office of Scientific Research, Medical Free-Electron Laser Program (FA9550-04-1-0101, F49620-00-2-0371)
  • The Beckman Foundation
  • ASLMS Student Travel Grant

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