Anticandidal activity of L-β-(isoxazolin-5-on-2-yl)-alanine due to the inhibition of O -acetyl-L-homoserine sulfhydrylase and cystathionine γ-synthase
Authors:
- Aleksandra KuplińskaAKAleksandra Kuplińska
- Edyta SkładanekESEdyta Składanek
- Hira Zahoor RajputHRHira Zahoor Rajput
- Joanna Stefaniak-SkorupaJSJoanna Stefaniak-Skorupa
- Kamila RządKRKamila Rząd
- Katarzyna Kozłowska-TylingoKKKatarzyna Kozłowska-Tylingo
- Marek WojciechowskiMWMarek Wojciechowski
- Milewska Maria JMJMilewska Maria J
- Iwona GabrielIwona Gabriel
- Sławomir MilewskiSławomir Milewski
Open Access
- 21 October 2026
- journal article
- research article
- Published by Taylor & Francis in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 41 (1) , 2749883
Abstract
Systemic mycoses, caused mainly in the immunocompromised patients by Candida spp. yeasts, especially C. albicans, are difficult to treat because of the small set of effective chemotherapeutics, eme...Keywords
Funding Information
- Polish National Science Centre (NCN (2020/39/B/NZ7/01519)
- from Gdansk University of Technology (DEC–2/2021/IDUB/V0.6/Si)
This publication has 45 references indexed in Scilit:
- Structural insight into the substrate specificity of cystathionine γ‐synthase from Lactobacillus plantarumFEBS Letters, 2026
- “Sandwich” Diimine‐Copper Catalysts for C−H Functionalization by Carbene InsertionAngewandte Chemie International Edition, 2022
- Identification of O‐acetylhomoserine sulfhydrylase, a putative enzyme responsible for methionine biosynthesis in Clostridioides difficile: Gene cloning and biochemical characterizationsIUBMB Life, 2019
- Inhibitors of amino acids biosynthesis as antifungal agentsAmino Acids, 2014
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibilityJournal of Computational Chemistry, 2009
- Aviglycine and propargylglycine inhibit conidial germination and mycelial growth of Fusarium oxysporumf. sp. luffaeMycopathologia, 2004
- Crystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitorJournal of Molecular Biology, 2001
- Role of O‐acetylhomoserine sulfhydrylase in sulfur amino acid synthesis in various yeastsYeast, 1993
- Broad antifungal activity of ?-isoxazolinonyl-alanine, a non-protein amino acid from roots of pea (Pisum sativum L.) seedlingsBiology and Fertility of Soils, 1991
- β-isoxazolinone-alanine is involved in the biosynthesis of the neurotoxin β-N-oxalyl-l-α,β-diaminopropionic acidPhytochemistry, 1990