Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia
Authors:
- Evgeny A MoskalevEMEvgeny A Moskalev
- Katrin LuckertKLKatrin Luckert
- Ivan A VorobjevIVIvan A Vorobjev
- Sergey E MastitskySMSergey E Mastitsky
- Aleena A GladkikhAGAleena A Gladkikh
- Achim StephanASAchim Stephan
- Marita SchrenkMSMarita Schrenk
- Kamil D KaplanovKKKamil D Kaplanov
- Olga B KalashnikovaOKOlga B Kalashnikova
- Oliver PötzOPOliver Pötz
- Thomas O JoosTJThomas O Joos
- Jörg D HoheiselJHJörg D Hoheisel
Open Access
- 6 June 2012
- journal article
- research article
- Published by Springer Nature in BMC Cancer
- Vol. 12 (1) , 213
Abstract
The Wnt/β-catenin signalling is aberrantly activated in primary B cell chronic lymphocytic leukaemia (CLL). Epigenetic silencing of pathway inhibitor genes may be a mechanism for its activation. In this study, we investigated systematically and quantitatively the methylation status of 12 Wnt/β-catenin pathway inhibitor genes – CDH1, DACT1, DKK1, DKK2, DKK3, DKK4, SFRP1, SFRP2, SFRP3, SFRP4, SFRP5 and WIF1 – in the cell lines EHEB and MEC-1 as well as patient samples.Keywords
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