Specific phosphorylation patterns control the interplay between aggregation and condensation of Tau-R4 peptides
Open Access
- 19 June 2025
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 23 (29) , 6912-6923
Abstract
Our study shows, by using synthetic multiphosphorylated peptide libraries that specific phosphorylation patterns govern the decision between aggregation and condensation of the R4 domain of the Tau protein.Keywords
Funding Information
- Horizon 2020 Framework Programme (101046369)
- Israel Science Foundation (1805/22)
- Alzheimer Nederland (WE.03-2019-03)
- Ministerie van Onderwijs, Cultuur en Wetenschap
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