T-SYSTEM OF THE BIRDS IMMUNITY UNDER THE INFLUENCE OF BEE PRODUCTS AND AGAINST THE BACKGROUND OF THE DEVELOPMENT OF CANDIDIASIS

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Abstract
The purpose of the research is to improve the system of prevention of candidiasis of the digestive tract of birds in quail farms. The research was carried out in the laboratories of the Russian State Agrarian University – the Timirya-zev Moscow Agricultural Academy. Quails of group 1 are healthy (control, without introducing biologically active bee products into the diet). Birds of the groups 2 and 6 were affected by candidiasis of the digestive tract. The birds of the groups 1 and 2 were in the same feeding and keeping conditions with quails of 3, 4, 5 (healthy) and 6 experimental groups, no additional manipulations were carried out with them. Wax moth extract was added to the diet of the birds of group 3, drone homogenate extract was added to the group 4, propolis extract was added to the group 5, propolis extract was added to the group 6 against the background of candidiasis of the digestive tract. It was found that the extract of cherry homogenate has a high biological activity, slightly inferior to it is the extract of propolis and then the extract of wax moth. The maximum increase in immunocompetent structural components – perivascular lymphoid couplings of the spleen of birds of groups 3, 4 and 5 was observed on day 60, compared with the data of quails of the group 2 affected by candidamycosis of the digestive tract, by 6.67, 8.89 and 7.78 times, the cortical substance of the thymus by 2.65, 3.39 and 2.79 times. To restore the morphofunctional activity of the spleen and thymus against the background of candidiasis of the digestive tract, propolis extract was selected as a more environmentally friendly and economical product for using in quail farming. Against the background of the development of candidamycosis of the digestive tract of quails (group 6), it contributed to the formation of T-dependent immunocompetent perivascular lym-phoid couplings of the spleen, which exceeded the indicator of the birds group 2 by the end of the experiment by 6.41 times, the cortical substance of the thymus by 2.46 times, which contributed to the strengthening of antibody processes in the spleen, slowing the timing of thymus involution in as a result of activation and restoration of the im-mune mechanisms of the whole organism of the birds.