Pregnancy Specific β1‐glycoprotein: Reference Values and Physiological Variations in Normal Pregnancy

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Abstract
A 90% general reference area of the pregnancy specific β1‐glycoprotein (SP‐1 or PSβG) is estimated on the basis of 387 samples from normal pregnancies. This is carried out by means of a rocket‐immunoelectrophoresis. In the second and third trimester the SP‐I concentration shows a skew distribution for which reason non‐parametric statistical methods are used. After birth of the placenta the half‐life of SP‐1 in serum is found to be of 34–60 hours. The day to day variations are found to be of 1.1%‐3.2% and the diurnal variations: 2.3% 6.4%. Serial determinations in 41 normal pregnancies show very limited divergencies from the average curve.SP‐1 concentration in the 37th week shows a negative correlation to maternal age, and positive correlations to placental weight and hPL in serum but not to the urinary excretion of estriol.It is concluded that to a reasonable degree the SP‐1 concentration in serum fulfil the criteria of a placental‐function variable. Because of the broad general reference area and the small divergencies in the individual course. serial determinations are expected to give more precise information than single determinations.
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