Klebsiella pneumoniae l- Fucose Metabolism Promotes Gastrointestinal Colonization and Modulates Its Virulence Determinants
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- 20 October 2022
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 90 (10) , e0020622
Abstract
Colonization of the gastrointestinal (GI) tract by Klebsiella pneumoniae is generally considered asymptomatic. However, gut colonization allows K. pneumoniae to either translocate to sterile site within the same host or transmit through the fecal-oral route to another host. K. pneumoniae gut colonization is poorly understood, but knowledge of this first step toward infection and spread is critical for combatting its disease manifestations. K. pneumoniae must overcome colonization resistance (CR) provided by the host microbiota to establish itself within the gut.Keywords
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Funding Information
- HHS | NIH | National Institute of Allergy and Infectious Diseases (5T32AI007401-28)
- HHS | NIH | National Institute of General Medical Sciences (T32GM127261)
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