Porcine Epidemic Diarrhea Virus Antagonizes Host IFN-λ-Mediated Responses by Tilting Transcription Factor STAT1 toward Acetylation over Phosphorylation To Block Its Activation
Open Access
- 27 June 2023
- journal article
- research article
- Published by American Society for Microbiology in mBio
- Vol. 14 (3) , e0340822
Abstract
PEDV has developed sophisticated evasion mechanisms to escape host IFN signaling via its structural and nonstructural proteins. STAT1 is one of the key transcription factors in regulating expression of ISGs.Keywords
Funding Information
- Zhejiang Provincial Key R&D Program of China (2022C02031)
- Zhejiang Provincial Key R&D Program of China (2021C02050)
- Zhejiang Provincial Key R&D Program of China (2021C02049)
- Science and Technology Innovation Leading Talents Project of ‘High-level Talents Special Support Plan’ of Zhejiang Province (2021R52041)
- Agricultural Major Technology Synergy Extension Project of Zhejiang Province (2021XTTGXM02-05)
- Fellowship of China Postdoctoral Science Foundation (2020M681880)
- National Natural Science Foundation of China (32202771)
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