Bifunctional Amine‐Squaramides: Powerful Hydrogen‐Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions
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- 15 January 2015
- journal article
- review article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 357 (2-3) , 253-281
Abstract
Organocatalytic domino/cascade reactions provide a convenient method for the construction of complex molecular structures bearing multiple stereocenters in a highly stereoselective fashion. Among various organocatalysts, bifunctional squaramides have emerged as powerful hydrogen‐bonding catalysts for promoting a wide array of useful asymmetric organocascade sequences. Higher activity and ease of preparation make these catalysts excellent alternatives for thiourea‐based organocatalysts. This review highlights the advances in the rapidly growing field of amine‐squaramide‐catalyzed domino/cascade reactions and their mode of action. magnified imageKeywords
This publication has 219 references indexed in Scilit:
- Chiral bifunctional squaramide catalyzed asymmetric tandem Michael-cyclization reaction: efficient synthesis of optically active 2-amino-4H-chromene-3-carbonitrile derivativesTetrahedron: Asymmetry, 2013
- Chiral squaramide as multiple H-bond donor organocatalysts for the asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefinsTetrahedron: Asymmetry, 2012
- A Continuum of Progress: Applications of N‐Hetereocyclic Carbene Catalysis in Total SynthesisAngewandte Chemie International Edition, 2012
- Organocatalytic Activation of Polycyclic Aromatic Compounds for Asymmetric Diels–Alder ReactionsAngewandte Chemie International Edition, 2012
- Organocatalytic Activation of Polycyclic Aromatic Compounds for Asymmetric Diels–Alder ReactionsAngewandte Chemie, 2012
- Exploiting Acyl and Enol Azolium Intermediates via N‐Hetero‐ cyclic Carbene‐Catalyzed Reactions of α‐Reducible AldehydesAdvanced Synthesis & Catalysis, 2012
- Organocatalytic Enantioselective Michael‐Addition of Malonic Acid Half‐Thioesters to β‐Nitroolefins: From Mimicry of Polyketide Synthases to Scalable Synthesis of γ‐Amino AcidsAdvanced Synthesis & Catalysis, 2011
- Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to IsatinsAdvanced Synthesis & Catalysis, 2011
- A novel C3-symmetric prolinol-squaramide catalyst for the asymmetric reduction of ketones by boraneTetrahedron: Asymmetry, 2011
- Squaramide‐Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to NitroalkenesAngewandte Chemie, 2009