Survivin as a Therapeutic Target for the Treatment of Human Cancer
Preprint
- 21 March 2024
- preprint
- Published by MDPI AG in Preprints.org
Abstract
Survivin was initially identified as a member of the inhibitor apoptosis (IAP) protein family and has been shown to play a critical role in regulation of both apoptosis and mitosis. Survivin has emerged as an attractive target for cancer therapy because its overexpression has been found in most human cancers and is frequently associated with chemotherapy resistance, recurrence, and poor survival rate in cancer patients. In this review, we discuss our current understanding of how survivin mediates various aspects of malignant transformation and drug resistance, as well as efforts that have been made to develop therapeutics targeting survivin for the treatment of cancer.Keywords
All Related Versions
- Version 1, 2024-03-21, Preprints
- Published version: Cancers, 16 (9), 1705.
This publication has 133 references indexed in Scilit:
- An Inhibitor of the Interaction of Survivin with Smac in Mitochondria Promotes ApoptosisChemistry – An Asian Journal, 2019
- Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53Archives of Toxicology, 2018
- Clinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant gliomaCancer Immunology, Immunotherapy, 2016
- The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage responseCancer Chemotherapy and Pharmacology, 2012
- Antitumor cytotoxic T-cell response induced by a survivin peptide mimicCancer Immunology, Immunotherapy, 2010
- Perinatal survivin is essential for the establishment of pancreatic beta cell mass in miceDiabetologia, 2009
- Nuclear survivin expression predicts poorer prognosis in glioblastomaJournal of Neuro-Oncology, 2008
- Expression of the NF‐κB targets BCL2 and BIRC5/Survivin characterizes small B‐cell and aggressive B‐cell lymphomas, respectivelyThe Journal of Pathology, 2005
- Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinomaCancer, 2005
- CRM1-Mediated Nuclear Export Determines the Cytoplasmic Localization of the Antiapoptotic Protein SurvivinExperimental Cell Research, 2002