Improving binding entropy by higher ligand symmetry? – A case study with human matriptase
- 27 April 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Medicinal Chemistry
- Vol. 14 (5) , 969-982
Abstract
Highly symmetric ligands can bind in multiple identical binding modes. The improved binding affinity arising from higher entropy was elucidated in this work.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (INST 247/921-1 FUGG)
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