Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon
Authors:
- Yuen P. TanYTYuen P. Tan
- Yongbo XueYongbo Xue
- Andrei I. SavchenkoASAndrei I. Savchenko
- Sevan D. HoustonSevan D. Houston
- Naphak ModhiranNMNaphak Modhiran
- Christopher L. D. McMillanCMChristopher L. D. McMillan
- Glen M. BoyleGlen M. Boyle
- Paul V. BernhardtPaul V. Bernhardt
- Paul R. YoungPYPaul R. Young
- Daniel WattersonDWDaniel Watterson
- Craig M. WilliamsCraig M. Williams
- 25 September 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 82 (10) , 2828-2834
Abstract
The highly oxygenated pimarane diterpenoids basimarols A, B, and C (3–5) were isolated from the plant species Basilicum polystachyon, which was collected within the Australian arid zone. Structure elucidation was performed using a suite of spectroscopic techniques, including X-ray crystallography. Anticancer and anti-DENV activity of 3–5 was explored, but only limited activity was observed. More extensive antiviral evaluation of stachyonic acid A (1), which was also isolated from B. polystachyon, revealed broad spectrum antiviral activity against West Nile virus (Kunjin strain, WNVKun) and human influenza viruses H1N1 and H3N2.Keywords
Funding Information
- Australian Research Council (FT110100851)
- University of Queensland
- QIMR Berghofer Medical Research Institute
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