Diseased Erythrocyte Enrichment Based on I-Shaped Pillar DLD Arrays

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Abstract
Enrichment of erythrocytes is a necessary step in the diagnosis of blood diseases. Due to the high deformability and viscosity of erythrocytes, they cannot be regarded as stable point-like solids, so the influence of their deformability on fluid dynamics must be considered. Therefore, by using the special effect of an I-shaped pillar (I-pillar) on erythrocytes, erythrocytes with different deformability can be made to produce different provisional distances in the chip, so as to achieve the separation of the two kinds of erythrocytes. In this study, a microfluidic chip was designed to conduct a control test between erythrocytes stored for a long time and fresh erythrocytes. At a specific flow rate, the different deformable erythrocytes in the chip move in different paths. Then, the influence of erythrocyte deformability on its movement trajectory was analyzed by two-dimensional finite element flow simulation. DLD sorting technology provides a new method for the sorting and enrichment of diseased erythrocytes.
Funding Information
  • National Natural Science Foundation of China (52130607, 52366009, GCJ2022-38, 2022CYZC-21, 22YF7GA163)
  • National Natural Science Foundation of China (52130607, 52366009, GCJ2022-38, 2022CYZC-21, 22YF7GA163)
  • Double First-Class Key Program of Gansu Provincial Department of Education (52130607, 52366009, GCJ2022-38, 2022CYZC-21, 22YF7GA163)
  • 2022 Gansu Provincial University Industry Support Plan Project (52130607, 52366009, GCJ2022-38, 2022CYZC-21, 22YF7GA163)
  • Key R&D Program of Gansu Province of China (52130607, 52366009, GCJ2022-38, 2022CYZC-21, 22YF7GA163)
  • Key Laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education (52130607, 52366009, GCJ2022-38, 2022CYZC-21, 22YF7GA163)

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