Green Synthesis of Silver Nanoparticles from Syzygium cumini (L.) Skeels Seed Extract and their Potential Medicinal Applications

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Abstract
Aim: Nanotechnology is considered as one of the fastest-developing areas in the biomedicine field. Hence, the green synthesis of silver nanoparticles from Syzygium cumini seed extract was carried out in this study. Methods: The synthesis of silver nanoparticles form Syzygium cumini seed extract was carried out in this study. The synthesized nanoparticles were characterized by UV-Vis spectroscopy, FTIR, SEM, XRD and EDX. They were evaluated for antioxidant, anti-inflammatory, antibacterial and anti-diabetic activity by DPPH inhibition, albumin denaturation inhibition, agar well diffusion, α-amylase and α-glucosidase assays respectively. Results: Results: The surface plasmon resonance at 430 nm confirmed the formation of silver nanoparticles. They are stable, spherical in shape with the size ranging from 30 to 90 nm. The DPPH inhibition % of silver nanoparticles varied from 7.91±0.39% to 68.35±0.76%. The % inhibition of albumin denaturation was comparable to the diclofenac. Further the results of antibacterial activity revealed that the zone of inhibition for all the test bacteria varied from 14.33±0.58 to 25.33±0.58 mm where B. cereus was more susceptible. In addition, the % inhibition of α-amylase and α-glucosidase varied from 19.91±0.15% to 61.43±0.31% and 15.26±0.11% to 55.38±0.20% respectively. Conclusion: This study is the first attempt of utilizing the silver nanoparticles synthesized from S. cumini seed extract for anti-diabetic activity. The study suggests that these nanoparticles could be well utilized in pharmaceutical industries as an efficient antioxidant, anti-inflammatory, antibacterial and anti-diabetic drug.
Funding Information
  • ‘KSTEPS, DST, GOVT. OF KARNATAKA’ with DST/KSTePS/Ph.D. fellowship (DST/KSTePS/Ph.D. Fellowship/ LIF-11:2021-22/1023)

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