Supplementary Figure S14 from TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells

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Abstract
Supplementary Figure S14. TR-107 treatment impacts the transcriptomic profile of DLD-1 cells. (A) and (B) RT-PCR analysis of components of ISR and ferroptosis pathways in DLD-1 after 24 and 72 hours of TR-107 treatment, respectively. The green lane denotes a 2-fold cut-off, and the red lane – is a 0.5-fold cut-off. Data are presented as mean ± SD values (N=3). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.