SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma
Open Access
- 26 November 2014
- journal article
- Published by Springer Nature in Molecular Cancer
- Vol. 13 (1) , 257
Abstract
Aberrant activation of the Wnt/beta-catenin signaling pathway is an important factor in the development of nasopharyngeal carcinoma (NPC). Previous studies have demonstrated that the developmental gene sex-determining region Y (SRY)-box 1 (SOX1) inhibits cervical and liver tumorigenesis by interfering with the Wnt/-catenin signaling pathway. However, the role of SOX1 in NPC remains unclear. This study investigates the function of SOX1 in NPC pathogenesis.Keywords
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