Role of IL‐10 in Inflammation: Studies Using Cytokine Knockout Micea

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Abstract
Interleukin‐10 (IL‐10) inhibits the synthesis of proinflammatory cytokines known to be involved in fever, including IL‐1, IL‐6, and tumor necrosis factor‐α. We hypothesized that IL‐10 modulates lipopolysaccharide (LPS)‐induced fever in mice. Body temperature was measured by biotelemetry. Swiss Webster mice injected with recombinant murine IL‐10 (rmuIL‐10) were resistant to fever induced by a low dose of LPS (100 μg/kg, ip) and to the hypothermic and febrile effects of a high (septic‐like) dose of LPS (2.5 mg/kg, ip). Injection of rmuIL‐10 alone had no effect on afebrile body temperature of Swiss Webster mice. IL‐10 knockout mice showed an exacerbated and prolonged fever in response to a low dose of LPS (50 μg/kg, ip) compared to their wild‐type counterparts. These data support the hypothesis that IL‐10 acts as an endogenous cryogen during LPS‐induced fever in mice.

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