Lisa R. Leon
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Lisa R. Leon has a total of 2 co-authors. Here are the top co-authors by number of shared publications:
Matthew J. Kluger
Lovelace Respiratory Research Institute, P.O. Box 5890, Albuquerque, New Mexico 87185, USA
1 shared publicationWieslaw Kozak
Lovelace Respiratory Research Institute, P.O. Box 5890, Albuquerque, New Mexico 87185, USA
1 shared publication
Latest Publications
- 1 September 1998
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 856 (1) , 69-75
Role of IL‐10 in Inflammation: Studies Using Cytokine Knockout Micea
Interleukin‐10 (IL‐10) inhibits the synthesis of proinflammatory cytokines known to be involved in fever, including IL‐1, IL‐6, and tumor necrosis factor‐α. We hypothesized that IL‐10 modulates lipopolysaccharide (LPS)‐induced fever in mice. Body temperature was measured by biotelemetry. Swiss Webster mice injected with recombinant murine IL‐10 (rmuIL‐10) were resistant to fever induced by a low dose of LPS (100 μg/kg, ip) and to the hypothermic and febrile effects of a high (septic‐like) dose of LPS (2.5 mg/kg, ip). Injection of rmuIL‐10 alone had no effect on afebrile body temperature of Swiss Webster mice. IL‐10 knockout mice showed an exacerbated and prolonged fever in response to a low dose of LPS (50 μg/kg, ip) compared to their wild‐type counterparts. These data support the hypothesis that IL‐10 acts as an endogenous cryogen during LPS‐induced fever in mice.
- 1 September 1998
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 856 (1) , 69-75
Role of IL‐10 in Inflammation: Studies Using Cytokine Knockout Micea
Interleukin‐10 (IL‐10) inhibits the synthesis of proinflammatory cytokines known to be involved in fever, including IL‐1, IL‐6, and tumor necrosis factor‐α. We hypothesized that IL‐10 modulates lipopolysaccharide (LPS)‐induced fever in mice. Body temperature was measured by biotelemetry. Swiss Webster mice injected with recombinant murine IL‐10 (rmuIL‐10) were resistant to fever induced by a low dose of LPS (100 μg/kg, ip) and to the hypothermic and febrile effects of a high (septic‐like) dose of LPS (2.5 mg/kg, ip). Injection of rmuIL‐10 alone had no effect on afebrile body temperature of Swiss Webster mice. IL‐10 knockout mice showed an exacerbated and prolonged fever in response to a low dose of LPS (50 μg/kg, ip) compared to their wild‐type counterparts. These data support the hypothesis that IL‐10 acts as an endogenous cryogen during LPS‐induced fever in mice.