Claire L. Meaney
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Claire L. Meaney has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Aidan J. Cloonan
Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
1 shared publication - Anna. V. Piterina
Department of Chemical and Environmental Sciences, Material and Surface Science Institute, University of Limerick, Limerick, Ireland
1 shared publication - Anthony Callanan
Centre for Applied Biomedical Engineering Research (CABER), Department of Mechanical and Aeronautical Engineering and Materials and Surface Science Institute, University of Limerick, Ireland
1 shared publication - Laura M. Davis
Centre for Applied Biomedical Engineering Research (CABER), Department of Mechanical & Aeronautical Engineering, and Materials and Surface Science Institute (MSSI), University of Limerick, Limerick, Ireland
1 shared publication - Michael T. Walsh
BioMaterials Cluster, Bernal Institute, University of Limerick, Limerick, Ireland
1 shared publication - Timothy M. McGloughlin
Centre for Applied Biomedical Engineering Research, Materials and Surfaces Science Institute, Mechanical, Aeronautical and Biomedical Engineering Department, University of Limerick, Limerick, Ireland; Department of Biomedical Engineering, Khalifa University of Science, Technology & Research (KUSTAR), P.O. Box: 127788, Abu Dhabi, UAE
1 shared publication
Latest Publications
- Open Access
- 12 October 2009
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 10 (10) , 4375-4417
ECM-Based Materials in Cardiovascular Applications: Inherent Healing Potential and Augmentation of Native Regenerative Processes
The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment.
- 12 October 2009
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 10 (10) , 4375-4417
Open AccessECM-Based Materials in Cardiovascular Applications: Inherent Healing Potential and Augmentation of Native Regenerative Processes
The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment.