Roberto Sakuraba
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Roberto Sakuraba has a total of 19 co-authors. Here are the top co-authors by number of shared publications:
- Ana Carolina Pires de Rezende
Radiotherapy Department, Hospital Israelita Albert Einstein, São Paulo, Brazil
1 shared publication - Ana Cláudia M Chiara
Instituto do Câncer do Estado de São Paulo (ICESP) Av. Dr Arnaldo, 251, 01246-000, São Paulo—SP, Brazil
1 shared publication - Andreza Alice Feitosa Ribeiro
Hospital Israelita Albert Einstein, Bone Marrow Transplantation Unit, Sao Paulo, Brazil
1 shared publication - Carolina Perrone Marques
Bone Marrow Transplant Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil
1 shared publication - Eduardo Weltman
Radiotherapy Department, Hospital Israelita Albert Einstein, São Paulo, Brazil
1 shared publication - Fernanda B C Nonato
Cidade Universitária
1 shared publication
Latest Publications
- Open Access
- 30 July 2026
- Published by Springer Nature in Current Tissue Microenvironment Reports
- Vol. 7 (1) , 7
Total marrow irradiation-based, reduced-intensity conditioning regimen for elderly patients undergoing hematopoietic cell transplantation for hematological malignancies
Background: Elderly patients are increasingly being offered allogeneic hematopoietic cell transplantation (HCT), and several strategies have been developed to meet their needs. The objective of the current study was to report the feasibility of a reduced-intensity busulfan/fludarabine conditioning regimen with total marrow irradiation in older patients. Methods: This single-center study included 28 patients aged 60–77 years with a median follow-up of 34 months. Results: Overall survival at 2 years was 46%, relapse rate was 30%, and non-relapse mortality was 23%, yielding a progression-free survival of 46%. Rates of grades II-IV acute GVHD, III-IV acute GVHD, and chronic GVHD were 47%, 8%, and 19%, respectively. Only one patient did not achieve neutrophil engraftment. Three patients experienced sinusoidal obstruction syndrome, and all recovered. Causes of death included disease progression ( n = 10), infection ( n = 5, including one COVID-19 case), and acute myocardial infarction ( n = 1). Conclusion: Our results demonstrate the feasibility of an intensified, total marrow irradiation-based conditioning regimen in an elderly cohort, primarily comprising transplants from alternative donors for high-risk diseases. Non-relapse mortality was very low, given the patients’ profile, and compares favorably with others reports reduced-intensity regimen with total body irradiation in older patients. Future studies should compare it to the standard reduced-intensity and non-myeloablative regimens.
- 30 July 2026
- Published by Springer Nature in Current Tissue Microenvironment Reports
- Vol. 7 (1) , 7
Open AccessTotal marrow irradiation-based, reduced-intensity conditioning regimen for elderly patients undergoing hematopoietic cell transplantation for hematological malignancies
Background: Elderly patients are increasingly being offered allogeneic hematopoietic cell transplantation (HCT), and several strategies have been developed to meet their needs. The objective of the current study was to report the feasibility of a reduced-intensity busulfan/fludarabine conditioning regimen with total marrow irradiation in older patients. Methods: This single-center study included 28 patients aged 60–77 years with a median follow-up of 34 months. Results: Overall survival at 2 years was 46%, relapse rate was 30%, and non-relapse mortality was 23%, yielding a progression-free survival of 46%. Rates of grades II-IV acute GVHD, III-IV acute GVHD, and chronic GVHD were 47%, 8%, and 19%, respectively. Only one patient did not achieve neutrophil engraftment. Three patients experienced sinusoidal obstruction syndrome, and all recovered. Causes of death included disease progression ( n = 10), infection ( n = 5, including one COVID-19 case), and acute myocardial infarction ( n = 1). Conclusion: Our results demonstrate the feasibility of an intensified, total marrow irradiation-based conditioning regimen in an elderly cohort, primarily comprising transplants from alternative donors for high-risk diseases. Non-relapse mortality was very low, given the patients’ profile, and compares favorably with others reports reduced-intensity regimen with total body irradiation in older patients. Future studies should compare it to the standard reduced-intensity and non-myeloablative regimens.
- 1 February 2016
- Published by IOP Publishing in Biomedical Physics & Engineering Express
- Vol. 2 (1) , 015011
Development and characterization tests of a homemade ionization chamber with silver collecting electrode for use in electron beams
Ionization chambers are special detectors for radiation beam dosimetry in hospitals. In this work, a PMMA parallel-plate ionization chamber with air sensitive volume was designed and built for use in electron beams of linear accelerators. This ionization chamber has a PMMA collecting electrode covered with silver paint. Several characterization tests were undertaken following international recommendations. The ionization chamber showed good performance in the characterization tests of its electrical properties and in most of the tests performed in the linear accelerator beams.
- 1 February 2016
- Published by IOP Publishing in Biomedical Physics & Engineering Express
- Vol. 2 (1) , 015011
Development and characterization tests of a homemade ionization chamber with silver collecting electrode for use in electron beams
Ionization chambers are special detectors for radiation beam dosimetry in hospitals. In this work, a PMMA parallel-plate ionization chamber with air sensitive volume was designed and built for use in electron beams of linear accelerators. This ionization chamber has a PMMA collecting electrode covered with silver paint. Several characterization tests were undertaken following international recommendations. The ionization chamber showed good performance in the characterization tests of its electrical properties and in most of the tests performed in the linear accelerator beams.