Kaiwen Su
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Kaiwen Su has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
- Aboozar Monavarfeshani
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA, USA
2 shared publications - Gail Stanton
Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, Roanoke, United States
2 shared publications - Jonathan Van Name
Virginia Commonwealth University School of Medicine (M.D. Class 2024), Richmond, VA, 23298, USA
2 shared publications - Kenya Swilling
Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, Roanoke, United States
2 shared publications - Michael Andrew Fox
Fralin Biomedical Research Institute at Virginia Tech Carilion Roanoke Virginia USA
2 shared publications - William A. Mills
Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, Roanoke, United States
2 shared publications
Latest Publications
- Open Access
- 9 February 2018
- Published by eLife Sciences Publications, Ltd in eLife
- Vol. 7
LRRTM1 underlies synaptic convergence in visual thalamus
It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted to the brain in unmixed, feature-specific channels. To faithfully convey feature-specific information from retina to cortex, thalamic relay cells must receive inputs from only a small number of functionally similar retinal ganglion cells. However, recent studies challenged this by revealing substantial levels of retinal convergence onto relay cells. Here, we sought to identify mechanisms responsible for the assembly of such convergence. Using an unbiased transcriptomics approach and targeted mutant mice, we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Importantly, LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of retinothalamic convergence in vision.
- 9 February 2018
- Published by eLife Sciences Publications, Ltd in eLife
- Vol. 7
Open AccessLRRTM1 underlies synaptic convergence in visual thalamus
It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted to the brain in unmixed, feature-specific channels. To faithfully convey feature-specific information from retina to cortex, thalamic relay cells must receive inputs from only a small number of functionally similar retinal ganglion cells. However, recent studies challenged this by revealing substantial levels of retinal convergence onto relay cells. Here, we sought to identify mechanisms responsible for the assembly of such convergence. Using an unbiased transcriptomics approach and targeted mutant mice, we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Importantly, LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of retinothalamic convergence in vision.
- Open Access
LRRTM1 underlies synaptic convergence in visual thalamus
It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted to the brain in unmixed, feature-specific channels. To faithfully convey feature-specific information from retina to cortex, thalamic relay cells must receive inputs from only a small number of functionally similar retinal ganglion cells. However, recent studies challenged this by revealing substantial levels of retinal convergence onto relay cells. Here, we sought to identify mechanisms responsible for the assembly of such convergence. Using an unbiased transcriptomics approach and targeted mutant mice, we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Importantly, LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of retinothalamic convergence in vision.
Open AccessLRRTM1 underlies synaptic convergence in visual thalamus
It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted to the brain in unmixed, feature-specific channels. To faithfully convey feature-specific information from retina to cortex, thalamic relay cells must receive inputs from only a small number of functionally similar retinal ganglion cells. However, recent studies challenged this by revealing substantial levels of retinal convergence onto relay cells. Here, we sought to identify mechanisms responsible for the assembly of such convergence. Using an unbiased transcriptomics approach and targeted mutant mice, we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Importantly, LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of retinothalamic convergence in vision.