Kieu The Loan Trinh

Cancer remains one of the main causes of death worldwide. The development of drug resistance, systemic toxicity, and poor therapeutic selectivity continues to limit the efficacy of conventional treatments. Multi-target therapeutic agents that can modulate complex oncogenic networks are gaining increasing interest among natural products. Alpinia galanga (L.) Willd. is a medicinal plant that is a promising source of bioactive compounds with high anticancer potential. This review summarizes the current evidence on the anticancer activities of A. galanga extracts and its major phytochemicals, including 1′-acetoxychavicol acetate (ACA), 1′-acetoxyeugenol acetate (AEA), galangin, chrysin, pinocembrin, and related flavonoids. Mechanistically, these compounds modulate various hallmarks of cancer by modulating oxidative stress, apoptosis, autophagy, cell-cycle arrest, mitochondrial dysfunction, inflammatory signaling, and metastatic pathways, particularly NF-κB, PI3K/Akt, MAPK, and p53-associated networks. Recent findings have shed light on the emerging roles of A. galanga compounds in overcoming resistance to targeted therapy, suppressing immune evasion through efferocytosis, remodeling the tumor microenvironment, and augmenting chemosensitivity and immunotherapeutic responses. Importantly, advances in nanotechnology-based formulations, such as lipid nanocarriers, exosome-mediated delivery systems, and biomimetic nanovaccines, have greatly improved the translational potential of galangin and other phytochemicals by improving their bioavailability, tumor targeting, and immune activation. This review also provides a critical discussion of the current pharmacokinetic limitations, translational challenges, and future opportunities for integrating A. galanga-derived compounds in precision oncology and combination-based cancer therapies. Collectively, the available evidence suggests that A. galanga is a platform with mechanistic versatility and clinical promise for next-generation anticancer therapeutics.

ZIF-L/Au composite was synthesized via a deep eutectic solvent (DES)-assisted green synthesis, and enabled colorimetric detection of trimethoprim with high sensitivity and selectivity.

Early diagnosis markedly improves therapeutic efficacy, recovery, and disease control. Microfluidic platforms based on isothermal nucleic acid amplification enable sensitive, rapid, and low‐volume detection of disease markers. This review provides a critical analysis of the integration of isothermal amplification techniques with microfluidic platforms for early detection of diseases, including cancer, infectious diseases, and genetic disorders. Key isothermal amplification methods—including loop‐mediated isothermal amplification (LAMP), recombinase polymerase amplification (RPA), and helicase‐dependent amplification (HDA)—are evaluated in terms of their underlying mechanisms, advantages, and limitations. The complementary combination of isothermal nucleic acid amplification with microfluidics represents a promising approach to enhance the early diagnostic of clinical samples. Importantly, the translation of these platforms into clinical practice has been validated through patient‐based studies and clinical trials, confirming their reliability as point‐of‐care diagnostics. Ongoing research continues to refine these technologies, resulting in several commercial products that address evolving diagnostic needs. Furthermore, the integration of artificial intelligence and machine learning approaches for automated signal interpretation and accelerated diagnostics is discussed. This review summarizes the current landscape of point‐of‐care devices and highlights strategies to enhance clinical outcomes, improve patient validation, and address current limitations.

This review summarizes recent advances in electrocatalytic PET upcycling, focusing on catalyst design, reaction mechanisms, integrated systems, and structure–activity relationships governing selective C1 and C2 product formation.

Metal nanoparticles have garnered significant attention due to their unique optical properties, which are highly advantageous in various sensing applications.

A novel approach integrating paper-based DNA extraction with digitized image analysis – assisted colorimetric LAMP was developed for colorimetric detection of Vibrio parahaemolyticus .

This study developed a nanoantibiotic based on bimetallic gold–platinum nanorods with enzyme-like activity for potential antimicrobial therapy.

A portable and fully-integrated point-of-care molecular diagnostic device detecting pathogenic Vibrio parahaemolyticus carrying pir A gene which causes Acute Hepatopancreatic Necrosis Disease in shrimp is developed.