Mansour Sadeghzadeh

Ossifying fasciitis represents an uncommon benign lesion within the spectrum of reactive fibroblastic proliferations. It is defined by the coexistence of spindle-cell proliferation and heterotopic bone formation, a combination that can easily simulate malignant soft-tissue tumors. Because of its rapid growth and radiologic density, it is frequently mistaken for sarcomatous processes. Although most cases occur in the trunk and proximal extremities, presentation within the hand is exceptionally rare. We describe a 34-year-old male who developed a painless nodule on the palmar aspect of the right hand growing over two months. Imaging revealed a well-circumscribed lesion with heterogeneous signal intensity adjacent to the flexor tendon. The excised mass was composed of fibroblasts and myofibroblasts arranged in fascicles within a fibromyxoid stroma, showing osteoid formation rimmed by osteoblasts and scattered multinucleated giant cells. No cytologic atypia or atypical mitoses were present. Immunohistochemistry demonstrated diffuse smooth-muscle-actin (SMA) positivity and absence of H-caldesmon and ALK expression, confirming a diagnosis of ossifying fasciitis. This case underscores the diagnostic pitfalls of ossifying fasciitis, particularly when arising in unusual anatomic locations. Awareness of its characteristic histologic features and correlation with clinical and imaging findings is crucial to avoid misinterpretation as a malignant neoplasm and to prevent unnecessary radical surgery. Reporting such cases expands understanding of their variable presentations and contributes to refining clinical decision-making.

Background: Intussusception is a rare late complication of Roux-en-Y gastric bypass (RYGB), and it is exceptionally uncommon to occur during pregnancy. Its diagnosis is difficult due to the overlapping of symptoms from normal pregnancy and limited options for imaging modalities. This case is notable for presenting in early pregnancy with bowel perforation and being successfully managed with emergency laparoscopy. Case Presentation: A 36-year-old female patient at 15 weeks of gestation (gravida 2, para 1, and living 1) was admitted with sudden onset of severe abdominal pain, weakness, and one episode of vomiting. Her history included RYGB, cesarean delivery, and cholecystectomy. Vital signs and laboratory tests were normal. Ultrasound examination of the abdomen revealed a dilated, noncompressible bowel loop in the right lower quadrant, which raised suspicion of obstruction. Laparoscopy showed marked dilation at the jejunojejunal anastomosis, a small anterior bowel perforation, and retrograde intussusception approximately 20 centimeters distal to the anastomosis. The perforation was repaired, the intussusception was reduced, and bowel viability was confirmed. Recovery was uneventful, with no maternal or fetal complications. Conclusions: This case highlights that intussusception should be taken into consideration in pregnant patients who have undergone gastric bypass and now present with acute abdominal pain. Ultrasound can be a useful diagnostic tool when other imaging modalities are restricted. Early laparoscopic intervention is critical to prevent severe complications and support favorable maternal and fetal outcomes.

Background: Hearing loss is increasingly recognized as a non‐motor manifestation of Parkinson's disease (PD), but its prevalence, characteristics, and underlying mechanisms remain unclear. This systematic review aims to evaluate the prevalence and characteristics of hearing loss in people with PD (PwPD). Methods: PubMed, Embase, and Web of Science were searched without restrictions. Observational studies assessing hearing loss in PwPD using pure tone audiometry (PTA), speech audiometry (SA), or central auditory processing (CAP) tests were included. Random‐effects models were applied, and heterogeneity was examined by meta‐regression. Results: Thirty‐five studies encompassing 1316 PwPD and 820 controls were included. Pooled prevalence indicated 73.9% (95% CI: 61.5%, 84.8%) of 1009 PwPD had hearing loss, with high‐frequency impairment (82.6%) more common than low‐frequency loss (45.1%). Compared with age matched controls, PwPD were 1.82 times more likely to experience hearing loss (odds ratio = 1.82; 95% CI: 1.19–2.78; PwPD = 599; healthy controls = 579). Older age and higher‐frequency testing predicted higher prevalence. SA results were inconsistent. CAP meta‐analyses revealed significant prolongation of brain stem auditory‐evoked potential wave III latency (standardized mean difference [SMD] = 0.51; 95% CI: 0.15–0.88), wave V latency (SMD = 0.73; 95% CI: 0.25–1.21), and I–V interpeak interval (SMD = 0.84; 95% CI: 0.41–1.27). Among late latency potentials, N200 latency (SMD = 0.60; 95% CI: 0.20–0.99) and P300 latency (SMD = 0.73; 95% CI: 0.49–0.98) were significantly delayed, while other components showed no group differences. Conclusions: Hearing loss is common in PD, extending beyond age‐related decline and likely involving both peripheral and central pathways. It may represent an early non‐motor symptom and a marker of cognitive vulnerability. © 2026 International Parkinson and Movement Disorder Society.

KCNC1‐related progressive myoclonus epilepsy (EPM7) is a rare disorder causing seizures, myoclonus, and ataxia. The first reported Iranian case highlights the role of genetic testing in diagnosis and potential future treatments, including gene therapy and novel pharmacological approaches.

The aim of asthma treatment is to reduce airway inflammation by avoiding environmental triggers and using daily anti-inflammatory medications. This study aimed to compare the effects of fluticasone propionate (FP) and budesonide (Bud) on the clinical symptoms and control of asthma in children with moderate to severe asthma. In this open-label study, children with moderate to severe asthma were randomly selected to receive either FP 250 mcg or Bud 400 mcg for 3 months. Asthma control test scores were measured in both groups monthly. The clinical symptoms, drug adherence, and rescue medication were also evaluated. A total of 50 patients with ages between 4 and 7 years old were included in the study (25 cases received Bud and 25 cases received FP). Asthma control test scores, daily and nocturnal symptoms, and cough rates were significantly improved in both groups. The average asthma control scores for the fluticasone group were 21.68±3.32 in the second month and 24.84±2.67 in the third month, whereas the budesonide group had scores of 18.52±3.32 and 22.48±4.12 during the same periods. These variances were statistically significant. Additionally, the requirement for salbutamol use was notably reduced in the fluticasone group compared to the budesonide group throughout all three months. The efficacy of fluticasone propionate in decreasing the need for rescue medication and enhancing asthma control test scores was markedly superior to that of budesonide.

Background and Objective: Febrile seizures are one of the most common neurological disorders in children. The aim of this study was to investigate the extent of abnormal EEG reports and its association with other risk factors of febrile seizures. Materials and Methods: In this prospective observational study, all patients with febrile seizure ...

Background: Bronchiolitis, the most common cause of hospitalization in infancy has not yet a definitive treatment. This study was conducted to assess the effect of Zinc and vitamin D on treatment of infants with bronchiolitis. Methods: In this double blind, randomized clinical trial, 94 infants aged 2 to 23 months, admitted in Mousavi Hospital in Zanjan, Iran, with the diagnosis of acute bronchiolitis were randomly assigned into 3 groups. The control group was only treated with hypertonic saline. The two case groups received either 100 unit/kg/day of Vitamin D or 20 mg/day of zinc in addition to hypertonic saline. Wheezing, duration of hospital stay, cough, cyanosis, respiratory distress and the respiratory rate in the first, third and seventh day of hospitalization were evaluated. Results: There was no significant difference between groups in terms of age, sex, weight, passive smoking, wheezing, oxygen saturation, cyanosis and type of delivery. On the third day of hospitalization, the respiratory rate/min in the control group, the groups receiving vitamin D and zinc were 45.2 ± 10.7, 37.8 ± 3.9 and 41.1 ± 9.1 respectively and the result of repeated measure analysis didn’t show any significant difference between the 3 groups (P = 0.562). Duration of hospitalization in the group receiving Vitamin D or zinc and in controls were 4.2 ± 2.6, 4.4 ± 2.2 and 5.1 ± 2.4 days respectively and this difference was not significant. Zinc receiving patients did not differ from the control group regarding to respiratory rate, cyanosis and wheezing. Conclusion: Vitamin D or zinc administration was not effective in reducing respiratory rate in children with bronchiolitis. Trial registration This project was approved by the Institutional Ethics Committee (IR, ZUMS.REC.1396.50), and registered on IRCT (IRCT20131217015835N7).

Background: This study aims to evaluate the effect of symbiotic (Pedilact) on the treatment of infantile colic. Materials and Methods: In this randomized clinical trial in Zanjan, Iran, 76 infants with infantile colic were assigned to two groups of 38 cases using block randomization. The intervention group received 5 drops of Pedilact, a symbiotic containing Lactobacillus reuteri and simethicone (20 mg twice daily), and the control group received placebo in addition to simethicone for 4 weeks. Daily crying time, number of crying attacks per day, and sleep duration were recorded on days 1, 7, 14, 21, and 28, and the results were compared. Results: Thirty-three infants in the intervention group and 35 infants in the control group were enrolled. There was no significant difference between the two groups in terms of age, gender, gestational age, maternal age, type of delivery, type of feeding, and weight at the beginning and the end of the study (all P > 0.05). Daily crying time in the control and intervention groups decreased from 240 and 210 min/day, respectively, to 0 min/day in both the groups. Daily crying attacks decreased from 5 and 4/day in the control and intervention groups, respectively, to 0/day. Sleep duration in both the groups increased from 720 to 840 and 930 min/day in the control and intervention groups, respectively, but the changes were not significant (P = 0.56, P = 0.52, and P = 0.13, respectively). Conclusion: We did not find a significant improvement in colic symptoms in infants receiving symbiotic compared to placebo.