Qiang Li
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Qiang Li has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Na Liang
College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China
2 shared publications - Pengfei Yan
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science Heilongjiang University, 74 Xuefu Road, Harbin 150080, China
2 shared publications - Shaoping Sun
Department of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, China
2 shared publications - Caixia Yan
Key Laboratory of Chemical Engineering Process & Technology for High-efficiency Conversion, College of Heilongjiang Province, School of Chemistry and Material Science, Heilongjiang University, Harbin, 150080, China
1 shared publication - Fude Cui
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
1 shared publication - Xianfeng Gong
Key Laboratory of Chemical Engineering Process & Technology for High-Efficiency Conversion, College of Heilongjiang Province; School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, China
1 shared publication
Latest Publications
- 1 July 2019
- Published by Elsevier in Carbohydrate Polymers
- Vol. 216, 129-139
Biotin and arginine modified hydroxypropyl-β-cyclodextrin nanoparticles as novel drug delivery systems for paclitaxel
- 1 July 2019
- Published by Elsevier in Carbohydrate Polymers
- Vol. 216, 129-139
Biotin and arginine modified hydroxypropyl-β-cyclodextrin nanoparticles as novel drug delivery systems for paclitaxel
- Open Access
- 23 May 2018
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 19 (6) , 1550
Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation
Amphiphilic polymer of α-tocopherol succinate modified glycol chitosan (TS-GC) was successfully constructed by conjugating α-tocopherol succinate to the skeleton of glycol chitosan and characterized by Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance (1H-NMR). In aqueous milieu, the conjugates self-assembled to micelles with the critical aggregation concentration of 7.2 × 10−3 mg/mL. Transmission electron microscope (TEM) observation and dynamic light scattering (DLS) measurements were carried out to determine the physicochemical properties of the micelles. The results revealed that paclitaxel (PTX)-loaded TS-GC micelles were spherical in shape. Moreover, the PTX-loaded micelles showed increased particle sizes (35 nm vs. 142 nm) and a little reduced zeta potential (+19 mV vs. +16 mV) compared with blank micelles. The X-ray diffraction (XRD) spectra demonstrated that PTX existed inside the micelles in amorphous or molecular state. In vitro and in vivo tests showed that the PTX-loaded TS-GC micelles had advantages over the Cremophor EL-based formulation in terms of low toxicity level and increased dose, which suggested the potential of the polymer as carriers for PTX to improve their delivery properties.
- 23 May 2018
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 19 (6) , 1550
Open AccessPolymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation
Amphiphilic polymer of α-tocopherol succinate modified glycol chitosan (TS-GC) was successfully constructed by conjugating α-tocopherol succinate to the skeleton of glycol chitosan and characterized by Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance (1H-NMR). In aqueous milieu, the conjugates self-assembled to micelles with the critical aggregation concentration of 7.2 × 10−3 mg/mL. Transmission electron microscope (TEM) observation and dynamic light scattering (DLS) measurements were carried out to determine the physicochemical properties of the micelles. The results revealed that paclitaxel (PTX)-loaded TS-GC micelles were spherical in shape. Moreover, the PTX-loaded micelles showed increased particle sizes (35 nm vs. 142 nm) and a little reduced zeta potential (+19 mV vs. +16 mV) compared with blank micelles. The X-ray diffraction (XRD) spectra demonstrated that PTX existed inside the micelles in amorphous or molecular state. In vitro and in vivo tests showed that the PTX-loaded TS-GC micelles had advantages over the Cremophor EL-based formulation in terms of low toxicity level and increased dose, which suggested the potential of the polymer as carriers for PTX to improve their delivery properties.