Jinlan Jiang

To study the impact of acetabular reaming depth on reconstruction of rotation center (RC) in unilateral primary total hip arthroplasty (UPTHA) and guide individualized preoperative design. 200 postoperative standard bilateral hip anteroposterior radiographs after UPTHA were included, which were collected from January, 2013 to June, 2017 in our hospital. Osteonecrosis of femoral head was the only diagnosis in this cohort. The parameters were measured on the anteropoterior radiographs by using RadiAnt DICOM viewer. The average of the thickness of the teardrop is about 6.13 ± 1.42 mm. The parameter a (the difference value of the distance of bilateral RC and midline) was positively correlated with the parameter e (the acetabular reaming depth), and the Pearson correlation coefficient was 0.49 when P = 0.05. Furthermore, the value of parameter (e) was 8.25 mm when a2 (the distance from the center of the prosthesis femoral head to the vertical line across the midpoint of pubic symphysis) equaled a1 (the distance from RC of the healthy femoral head to the vertical line across the midpoint of pubic symphysis). The reaming depth of the acetabulum could influence the reconstruction of RC during UPTHA. When the medial margin of the cup was placed about 2 mm to the lateral border of the ipsilateral teardrop (the bottom of the ovum), the rotation center would be accurately restored.

Gold nanorods (GNRs) have become an attractive candidate in photothermal ablation against cancer cells for their excellent photothermal transduction effect. However, the applications of GNRs in nanomedicine have been obstructed by the high cytotoxicity from the surfactant. Mass efforts have been attempted to develop the GNRs with high photothermal transduction efficiency and exploit modification materials to low the cytotoxicity of the GNRs. In this paper, (+)-catechin, a natural polyphenol extracted from green tea with anti-oxidization activity, was chosen as an effective reductant through seedless method to synthesize GNRs with a high quality, which also exhibited an excellent photothermal transduction efficiency (57.9%). Red blood cells (RBC) membranes were exploited as the biomimetic coating materials to encapsulate the GNRs to enhance the biocompatibility and photothermal stability, which could finally realize the highly photothermal ablation effect against the melanoma cells. Such cell membrane-based biomimetic nanomaterials might have a great potential in future photothermal therapy.

Natural killer (NK)-cell-based immunotherapy has been reported to have promising prospects in the treatment of non-small cell lung cancer, one of the most common malignancies in the world. It has been proven that higher the NK cell infiltration into the tumor, the better is the curative effect. Therefore, it would be beneficial to develop a method that increases NK cell recruitment and infiltration into the tumor site. The purpose of this study was to establish an immune-cell delivery system for clear lung cancer cells based on magnetic nanoparticle (NP)-labeled NK cells that can be accumulated at the tumor site by placing a tiny external magnetic device inside animals. We developed superparamagnetic iron oxide NPs consisting of a magnetic Fe₃O₄ core and a shell of polydopamine (PDA) for magnetic targeting therapy. Fe₃O₄@PDA NPs possess favorable physiological stability and biocompatibility that facilitate their active uptake by NK cells. The biology of NK cells was not affected by the presence of NPs. In vitro and in vivo studies showed that Fe₃O₄@PDA NP-labeled NK cells significantly inhibited tumor growth and reduced the expression of Ki-67 and increased the apoptosis of A549 cancer cells. H&E staining showed Fe₃O₄@PDA NP-labeled NK cells, under a magnetic field, had higher intra-tumoral iron density and increased accumulation of CD56⁺ NK cells. Our results suggest that Fe₃O₄@PDA NPs are a promising magnetic nanomaterial that can manipulate immune cells, thereby inhibiting tumor growth.

Au nanorods (AuNRs) have attracted extensive attention in diagnosis and therapy, because of their excellent photothermal effects. Although many of attempts have been employed to prepare AuNRs with a good-size monodispersity, facile and feasible preparation methods are still welcomed in consideration of theranostics-related photothermal applications. In this work, AuNRs are prepared through a seedless method using hydroquinone as the reductant. The longitudinal located surface plasmon resonance peak of the as-prepared AuNRs can be tuned from 650 to 840 nm and the AuNRs indicate a good photothermal conversion efficiency. To lower the toxicity, natural red blood cell membranes are employed to coat the AuNRs. In the primary experiment in vitro, red blood cell membrane-coated AuNRs exhibit good biocompatibility and photothermal treatment effect.

Iron oxide (Fe₃O₄), polydopamine (PDA), and in particular their composites are examples of the safest nanomaterials for developing multifunctional nanodevices to perform noninvasive tumor diagnosis and therapy. However, the structures and performances of Fe₃O₄–PDA nanocomposites should be further perfected to enhance the theranostic efficiency. In this work, we demonstrate the fabrication of PDA-capped Fe₃O₄ (Fe₃O₄@PDA) superparticles (SPs) employing preassembled Fe₃O₄ nanoparticles (NPs) as the cores. Owing to the collective effect of preassembled Fe₃O₄ NPs, the superparamagnetism and photothermal performance of Fe₃O₄@PDA SPs are greatly enhanced, thus producing nanodevices with improved magnetic resonance imaging (MRI)-guided photothermal efficiency. Systematical studies reveal that the molar extinction coefficient of the as-assembled Fe₃O₄ SPs is 3 orders of magnitude higher than that of individual Fe₃O₄ NPs. Also due to the high aggregation degree of Fe₃O₄ NPs, the T₂-weighted MRI contrast is greatly enhanced for the SPs with r₂ relaxivity of 230.5 mM^–1 s^–1, which is ∼2.5 times larger than that of individual Fe₃O₄ NPs. The photothermal stability, physiological stability, and biocompatibility, as well as the photothermal performance of Fe₃O₄ SPs, are further improved by enveloping with PDA shell.

Carbon nanoparticles (C-NPs) are novel and competitive luminescent materials both in academic research and practical applications owing to their environment-friendly behavior and high abundance on Earth. Despite the successes in preparing strongly luminescent C-NPs, preserving the luminescence in solid materials is still challenging. With the aim to produce C-NP-based white-light-emitting diodes (WLEDs), in this work, solvent-dispersible C-NPs are embedded into commercial silica gel via a dual solvent evaporation route. The basic idea is to lower the evaporation rate of the solvents, thus leading to a good dispersion of the C-NPs in the silica gel. This method avoids the aggregation-induced emission quenching of C-NPs in solid materials, and therefore preserves the strong luminescence in the C-NPs/silica gel composites. The composites are further blended with polydimethylsiloxane and act as the color conversion layer on InGaN UV-blue emitting chips, which produces LEDs with a bright white emission.