CLCinthya Yanina Santa Cruz López

Cinthya Yanina Santa Cruz López

*This is an algorithmically generated author record based on publicly available information.

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Cinthya Yanina Santa Cruz López has a total of 40 co-authors. Here are the top co-authors by number of shared publications:


Latest Publications

  • Open Access

    Conocimientos y prácticas preventivas sobre infecciones de transmisión sexual en estudiantes universitarios de Jaén

    by Cinthya Yanina Santa Cruz López, Helly Rosa Cruz Irrazabal, Marcela Yvone Saldaña Miranda, Ronald Arturo Cruz Silva

    The aim of this study was to evaluate the level of knowledge and preventive practices regarding STIs among university students in Jaén during 2023. A descriptive, cross-sectional study was conducted involving 260 university students of both sexes, aged over 17, selected through non-probability sampling. Data collection was carried out using a 20-question multiple-choice questionnaire, previously validated by expert judgment. Data were analyzed using Minitab 19 statistical software, and the Chi-square test was applied. Of the total participants, 55.4% were male, and 70.4% were aged between 17 and 21. Regarding STIs, 61.2% demonstrated an intermediate level of knowledge, while 11.2% showed a low level. Additionally, 89.6% exhibited an intermediate level of preventive practices. A statistically significant association was identified between gender and preventive practices (p = 0.005). In conclusion, university students demonstrate a moderate level of knowledge and preventive practices regarding STIs, highlighting the need to strengthen sex education strategies within the university setting.

  • Open Access

    Diagnostic Comparison Between Reagent Strips, Urinary Sediment and Urine Culture in Urinary Tract Infections: A Cross-sectional Study

    by Ximena Desiree López – Gallego, Koraima Ailyn Gonzáles – Díaz, Cinthya Yanina Santa Cruz – López, Ronald Arturo Cruz – Silva, Julio Cesar Montenegro – Juárez, Marcela Yvone Saldaña – Miranda

    This study aimed to compare urine sediment microscopy and reagent strips with urine culture for the diagnosis of urinary tract infections in outpatients in Jaén, Peru, in 2025. The research was comparative with a quantitative approach. A quantitative, comparative, non-experimental, cross-sectional. The sample consisted of 250 patients over 18 years of age of both genders, evaluated between March and May 2025. Three brands of reagent strips were used (Medi Test combi, ComboStik, and Mission), prioritizing the detection of nitrites and leukocyte esterase. Microscopic examination of the urine sediment assessed the presence of leukocytes (> 5 fields) and the number of organisms per field observed. A urine culture was used as the reference standard, with significant bacteriuria defined as bacterial growth ≥10⁵ CFU/mL on MacConkey and CLED agar. Additionally, the diagnostic performance of the techniques employed was evaluated by calculating sensitivity, specificity, predictive values, and the concordance index. The prevalence of urinary tract infection was 34.8%. Among the reagent strips evaluated, the Mission (sensitivity: 51.72%; specificity: 87.12%) and ComboStik (sensitivity: 47.13%; specificity: 91.41%) brands demonstrated the best performance for leukocyte esterase detection. Meanwhile, urinary sediment microscopy achieved a sensitivity of 100.00% and a specificity of 88.48% for leukocyte detection. In conclusion, urinary sediment microscopy was the best-performing test for diagnosing urinary tract infections. Among the reagent strips, Mission and ComboStik yielded the best results, particularly regarding the leukocyte esterase parameter.

  • Open Access

    Effect of Temperature on the Drying Kinetics of Caturra Coffee: Correlation with Hyperspectral Imaging and Sensory Quality

    by Frank Fernandez-Rosillo, Nestor A. Sánchez-Goycochea, Cinthya Santa Cruz-López, Eliana Milagros Cabrejos-Barrios, Jorge Caucha-Iparraguirre, Flor Garcia-Carrión, Lenin Quiñones-Huatangari

    Coffee processing requires continuous optimization to preserve sensory quality while improving process efficiency. Although hyperspectral imaging has been widely applied for food quality evaluation, its use for predicting coffee cup score during controlled drying remains limited. This study aimed to evaluate the effect of drying temperature on the drying kinetics of Caturra coffee and to develop a predictive model for cup score using hyperspectral imaging combined with Partial Least Squares Regression (PLSR). Coffee samples were dried at four constant temperatures (30, 40, 50, and 60 °C) in forced-convection ovens, and hyperspectral reflectance images (400–1000 nm) were acquired using a Specim FX10 camera. Sensory evaluation was conducted by six certified Q Arabica Graders. Drying times were 52, 34, 30, and 20 h at 30, 40, 50, and 60 °C, respectively, with corresponding cup scores of 83.21, 83.50, 83.60, and 83.26 points. Effective moisture diffusivity ranged from 10−13 to 10−12 m2/s, while mass transfer coefficients were on the order of 10−9 m/s, with activation energies of 28.016 and 19.272 kJ/mol. No significant differences in cup score were observed among drying temperatures (p>0.05). A PLSR-based model was developed to estimate cup score from hyperspectral data, achieving R2 values of 0.770 and 0.855 and RMSE values of 0.515 and 0.518 for calibration and validation, respectively. Key wavelengths at 480, 600, 720, and 940 nm were identified as the most influential spectral regions associated with chemical compounds affecting sensory quality. These findings demonstrate the potential of integrating drying kinetics and hyperspectral imaging as a rapid and non-destructive approach for objective prediction of coffee sensory quality during processing.


  • Seroprevalence and epidemiological characterization of Leptospira spp. in febrile patients from the epidemiological surveillance system in Jaén and San Ignacio, Cajamarca, Peru, 2021-2023

    by Cinthya Yanina Cruz-López, Marcela Saldaña-Miranda, Xiommara Alvarado-Dávila, Magaly Del Maestro-Morales, Christian Rivera-Salazar, Blanca Zulueta-Vásquez

    Leptospirosis is a bacterial zoonosis of public health importance. Objective:To determine the seropositivity, epidemiological characteristics, and distribution of Leptospira spp. serovars in febrile patients from the epidemiological surveillance system of Ministry of Health facilities in Jaén and San Ignacio, Cajamarca, Peru, during 2021–2023. Methods: An observational, cross-sectional, and retrospective study was conducted based on the secondary analysis of a database from the epidemiological surveillance system. A total of 4,489 blood samples from febrile patients of both sexes, with negative results for dengue, Zika, and chikungunya, were included. All samples were tested using IgM ELISA for Leptospira spp.; reactive or indeterminate samples were further evaluated using the microscopic agglutination test (MAT) for conrmation and serovar identication. Descriptive analysis and chi-square tests were performed. Results:IgM reactivity by ELISA was 28.4% (1276/4489), and 10.8% (485/4489) of samples were indeterminate. Among the 1,761 ELISA-reactive or indeterminate samples, 89.9% (1584/1761) were seropositive by MAT. Seropositivity was similar between women and men (89.6% vs. 90.4%; p = 0.576), but was higher in adults aged 30–59 years (92.3%; p = 0.007). The districts with the highest frequency of seropositive cases were Jaén (21.2%), San Ignacio (17.3%), and Morro Solar (12.9%). The most frequent serovars were Varillal (46.34%), Hurstbridge (14.16%), Icterohaemorrhagiae (10.88%), and Bratislava (6.18%). Conclusion: Seropositivity to Leptospira spp. was high among febrile patients in the epidemiological surveillance system of Jaén and San Ignacio, with higher frequency in adults aged 30–59 years

  • Open Access

    Análisis microbiológico y resistencia antibiótica en bacterias patógenas procedentes de quesos artesanales comercializados en Jaén, Perú

    by Ana Isabel Borja–Diaz, Brijhit Caruajulca–Lozano, Christian Alexander Rivera–Salazar, Cinthya Yanina Santa Cruz–López

    El queso fresco artesanal es un alimento muy consumido que puede convertirse en vehículo de transporte para bacterias potencialmente patógenas y farmacorresistentes. El objetivo del estudio fue realizar un análisis microbiológico y evaluar la resistencia antibiótica de bacterias patógenas provenientes quesos artesanales de mercados de Jaén, 2025. El estudio fue descriptivo con un enfoque cuantitativo, no experimental. Se analizaron 120 muestras de queso fresco (10 gramos cada una), para la cuantificación de coliformes totales y mesófilos procedentes de ocho mercados del distrito de Jaén. Se incluyeron muestras con almacenamiento no mayor a 3 días y procedentes de puestos de venta formal. El queso fue recolectado en bolsas ziploc estériles, etiquetadas y transportadas en condiciones asépticas y de refrigeración (4°C). Se prepararon diluciones seriadas siendo la solución madre la dilución 10-1. Sumado a ello, se demostró bioquímicamente la presencia de Escherichia coli y Staphylococcus aureus, también se identificó fenotípicamente las cepas productoras de betalactamasas de espectro extendido y resistentes a meticilina, respectivamente. Entre los resultados, se reportó una elevada carga microbiana para mesófilos (4,80 × 105 UFC/g) y coliformes totales (1,22 x 10⁴ UFC/g). Estos valores superaron los limites permisibles, siendo el Mercado Santa Rosa donde se reportó la mayor carga bacteriana. Además, se identificó S. aureus (35,00 %) y E. coli (21,67 %) en quesos artesanales. Se evidenció E. coli productoras de betalactamasas de espectro extendido y de S. aureus resistente a meticilina en el 100,00 y 14,29 % de las cepas, respectivamente. En conclusión, los quesos frescos artesanales comercializados en la ciudad de Jaén presentan niveles altos de mesófilos y coliformes totales, además, se evidenció la presencia de cepas E. coli betalactamasas de espectro extendido y S. aureus resistentes a meticilina.

  • Open Access

    Conocimiento sobre prevención y control de parasitosis intestinales en madres de infantes de Jaén, Perú

    by Cinthya Yanina Santa Cruz López, Marcela Saldaña Miranda, Rosario Yaqueliny Llauce Santamaria, Nsk Amarildo Carrasco Solano

    Introducción: Las parasitosis intestinales afectan negativamente la calidad de vida y salud de millones de personas. Es necesario poseer conocimientos generales sobre estas infecciones y sus medidas preventivas para establecer estrategias sanitarias adecuadas y sostenibles. Objetivo: El estudio tuvo como objetivo determinar el nivel de conocimiento sobre las medidas preventivas y control de las parasitosis intestinales en madres de infantes de Jaén, Perú 2021. Métodos: La muestra estuvo conformada por 383 madres de familia que habitan en la provincia de Jaén, departamento Cajamarca, Perú. Se incluyeron a 314 madres mayores de 18 años, con hijos menores de seis años, residentes por seis meses o más en la provincia de Jaén. Se empleó un cuestionario validado por juicio de ocho expertos y compuesto por 20 preguntas de opción múltiple. Resultados: El nivel conocimiento sobre las medidas preventivas y de control frente a las parasitosis intestinales fue regular en el 54,1% de las madres encuestadas. El 29,0% de las madres tenía 26 y 35 años de edad y el 38,2% manifestaron tener tres hijos o más. El 33,9% y 58,2% de mujeres con conocimiento deficiente y regular de las parasitosis intestinales solo culminaron sus estudios primarios y secundarios, respectivamente. El 55,6% que se desempeñaban como amas de casa presentaron un conocimiento regular (p<0,05). Conclusión: Se concluyó que el nivel de conocimiento fue regular y estuvo relacionado con la ocupación y grado de instrucción de las madres de infantes residentes en la provincia de Jaén.

  • Open Access

    Comparación de técnicas coproparasitológicas para el diagnóstico de geohelmintos intestinales en niños Lambayecanos

    by Cinthya Yanina Santa Cruz – López, Fransk Amarildo Carrasco Solano, Martha Arminda Vergara Espinoza, Melgy Sánchez Fernandez

    Los helmintos transmitidos a través del suelo pueden afectar el desempeño educativo y desenvolvimiento normal de los niños. Objetivo: comparar cinco técnicas coproparasitológicas para el diagnóstico de geohelmintos intestinales en niños lambayecanos. Métodos: estudio descriptivo de corte transversal. Se recolectaron 150 muestras de materia fecal de niños que residían en los distritos de Túcume y Lambayeque en el departamento de Lambayeque (Perú), durante el año 2021. Los niños y niñas tenían entre 4 y 12 años de edad. Previo a la recolección, se les explicó a los padres de familia y apoderados de los menores las condiciones preclínicas adecuadas. Se calculó la sensibilidad, especificidad, concordancia, valor predictivo positivo y negativo de las técnicas de Baerman, sedimentación rápida, Willis Molloy, Sheathers Sugar y examen directo de heces. Los padres y apoderados autorizaron la participación de los menores en el estudio. El estudio contó con la aprobación del comité de ética de la Universidad Nacional de Jaén. Resultados: la prevalencia geohelmintos intestinales fue del 20,7%, 19,3% y 18,0% con las técnicas de Baerman, sedimentación rápida y examen directo, respectivamente. Además, las técnicas de Baerman y de sedimentación rápida reportaron mayor sensibilidad, especificidad, valor predictivo positivo y negativo. Se obtuvo alto índice de concordancia para las técnicas de Baerman (0,894) y sedimentación rápida (0,891). Conclusiones: las técnicas de Baerman y de sedimentación rápida permitieron mayor recuperación de parásitos, respecto al examen directo. Además, las especies de geohelmintos intestinales más identificadas en niños lambayecanos fueron Ascaris lumbricoides, Hymenolepis nana y Ancilostomideos.


  • Open Access

    Factors associated with excess body weight in university students in times of COVID-19

    by Cinthya Santa Cruz López, Sheyla Tenorio Villanueva, Dámaris Pérez Ramírez, José Cabrejo Paredes

    Introduction: Excess body weight affects the quality of life of millions of young people around the world. Objective: To determine the factors associated with the prevalence of overweight and obesity in university students during COVID-19, from October to December 2020. Methods: Analytical, cross-sectional research with non-experimental design. There was a population of 325 students of the professional career of medical technology and a sample of 169 students of both sexes. Body mass index and waist circumference diameter were used to calculate overweight and obesity. The associated factors were determined by means of a survey validated by expert judgment. Results: 49.1% of the students were overweight or obese, with females being the most affected. Of overweight or obese students, 59.0% were at high risk of abdominal obesity. According to eating habits, 97.6% of young people ate three or more meals per day, 81.9% consumed foods rich in carbohydrates and 54.2% consumed junk food 1 -2 times per week. In relation to sedentary lifestyle, 71.0% of students remained seated between 5 and 8 hours a day, 67.4% slept less than 7 hours a day and 57.8% did not perform any physical activity. Conclusions: The intake of food with high carbohydrate content, junk food, hours spent sleeping and sitting daily are the factors associated with the high prevalence of overweight and obesity among students during the COVID-19 period.


  • Open Access

    ETIOLOGY OF URINARY INFECTIONS AND PREVALENCE OF Escherichia coli, PRODUCER OF EXTENDED SPECTRUM BETALACTAMASES AND CARBAPENEMASES

    by Sharon Díaz Velásquez, Karem Castañeda Torres, Cinthya Santa Cruz López, Fransk Carrasco Solano, Mario Moreno Mantilla

    Las infecciones ocasionadas por bacterias resistentes a múltiples antibióticos son de preocupación mundial. Por lo que, la investigacióndeterminó la etiología de infecciones urinarias y la prevalencia de Escherichia coli productora de betalactamasas de espectro extendido ycarbapenemasas en pacientes atendidos en la ciudad de Chiclayo, durante mayo a diciembre del 2018. Se trató de un estudio descriptivo,transversal y prospectivo con diseño no experimental. La población estuvo conformada por 201 pacientes con sospecha de infecciónurinaria. Se incluyeron muestras de orina de pacientes de ambos sexos atendidos en dos laboratorios clínicos privados. El aislamiento eidentificación de bacterias causantes de infecciones urinarias se realizó en Agar Mac Conkey y CLED, seguido de la identificación bioquímicay determinación de susceptibilidad antibiótica in vitro utilizando el método de disco difusión en agar. Para la detección fenotípica de cepasde E. coli productoras de betalactamasas de espectro extendido (BLEE) y carbapenemasas se emplearon los métodos de Jarlier y BLUECARB, respectivamente. El patógeno bacteriano más frecuente fue E. coli (57,71%), seguido de Staphylococcus coagulasa negativa (13,93%)y Klebsiella sp. (8,46%). Se observó mayor resistencia a la ampicilina, amoxicilina-ácido clavulánico y norfloxacino. El 55,17% de cepas de E.coli aisladas presentó resistencia a los antibióticos. El 68,75% de las cepas de E. coli produjeron BLEE y el 31,25% carbapenemasas. Enconclusión, la bacteria más aislada de infecciones urinarias fue E. coli, determinándose una alta prevalencia de cepas productoras de BLEEy carbapenemasas con mayor frecuencia en mujeres entre 39 y 46 años. Palabras clave: Betalactamasas, carbapenémicos, infección por Escherichia coli, resistencia a los antibióticos, tracto urinario. Abstract Infections caused by bacteria resistant to multiple antibiotics are of worldwide concern. Therefore, the research determined theetiology of urinary tract infections and the prevalence of Escherichia coli producer of extended-spectrum beta-lactamase-producingand carbapenemases in patients treated in the city of Chiclayo, during May to December 2018. This was a descriptive, cross -sectional,prospective study with non-experimental design. The population consisted of 201 patients with suspected urinary tract infection. Urinesamples from patients of both sexes attended in two private clinical laboratories were included. The isolation and identification ofbacteria causing urinary tract infections was performed on Mac Conkey and CLED Agar, followed by biochemical identification a nddetermination of antibiotic susceptibility in vitro using the agar diffusion disc method. For phenotypic detection of extended-spectrumbeta-lactamase (BLEE) and carbapenemase-producing E. coli strains, the Jarlier and BLUE CARB methods were used, respectively. Themost frequent bacterial pathogen was E. coli (57.71%), followed by coagulase-negative Staphylococcus (13.93%) and Klebsiella sp.(8,46%). Greater resistance was observed to ampicillin, amoxicillin-clavulanic acid and norfloxacin. Resistance to antibiotics wasobserved in 55.17% of the isolated E. coli strains. A total of 68.75% of the E. coli strains produced BLEE and 31.25% carbapenemases.In conclusion, E. coli was the bacterium most frequently isolated from urinary tract infections, with a high prevalence of BLEE andcarbapenemase-producing strains, with a higher frequency in women between 39 and 46 years of age. Keywords: Antibiotic resistance, beta-lactamases, carbapenems, Escherichia coli infection, urinary tract. * Autor para correspondencia: E. mail: cisantacruzl@gmail.com DOI: http://dx.doi.org/10.17268/rebiol.2021.41.02.03

  • Open Access

    Seroprevalencia de anticuerpos contra la Brucella sp. en ganaderos del distrito San José de Lourdes, Cajamarca

    by Escolana Julcahuanca, Edit Pérez, Cinthya Santa Cruz-López, Marcela Saldaña

    Objective. To determine the seroprevalence of antibodies against Brucella sp.and to identify the predisposing factors and associated symptomatology in cattle farmers in the San José de Lourdes district (San Ignacio) in the department of Cajamarca, during the months of September to December 2019. Methods.The study was observational, cross-sectional, prospective with an exploratory-descriptive design. A probabilistic sampling was carried out, where 147 blood serums belonging to cattle of both genders were analyzed. The seroprevalence of antibodies was determined by Rose Bengal and Huddleson antigen tests and a structured survey was applied to identify predisposing factors and symptoms associated with the disease. Results. It was found that 17 % of cattle farmers seropositive for Brucella sp. had prolonged direct contact with cattle (p < 0.05). In addition, 23.8 % of farmers had antibodies against Brucella sp., being mainly women (15.6%). Cattle farmers with antibodies against Brucella sp. consumed cheese (22.4%), milk (19.7 %) and blood from slaughtered animals (17 %) (p > 0.05). The most recurrent symptoms were headache (19 %), fatigue (14.3 %), joint pain (13.6 %), fever and insomnia (10.2 %). Conclusion.The seroprevalence of antibodies against Brucella sp. is high and is associated with prolonged direct contact with cattle and symptoms such as headache and fever, present in the population evaluated. The results obtained show the worrying situation of the cattle farmers of San José de Lourdes, in addition to the scarce preventive culture that exists.