Josh M. Leipheimer
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Josh M. Leipheimer has a total of 16 co-authors. Here are the top co-authors by number of shared publications:
- Max L. Balter
Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, USA
2 shared publications A. Shrirao
Department of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA
1 shared publicationA.I. Chen
Department of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA
1 shared publication- Alex Fromholtz
Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854
1 shared publication Alexander E. Davidovich
Icahn School of Medicine, Mount Sinai Hospital, 1 Gustave L. Levy Place, New York, NY 10029-5674, USA
1 shared publicationAlvin I. Chen
Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA
1 shared publication
Latest Publications
- 1 September 2019
- Published by World Scientific Pub Co Pte Ltd in TECHNOLOGY
- Vol. 07 (03n04) , 98-107
First-in-human evaluation of a hand-held automated venipuncture device for rapid venous blood draws
Obtaining venous access for blood sampling or intravenous (IV) fluid delivery is an essential first step in patient care. However, success rates rely heavily on clinician experience and patient physiology. Difficulties in obtaining venous access result in missed sticks and injury to patients, and typically require alternative access pathways and additional personnel that lengthen procedure times, thereby creating unnecessary costs to healthcare facilities. Here, we present the first-in-human assessment of an automated robotic venipuncture device designed to safely perform blood draws on peripheral forearm veins. The device combines ultrasound imaging and miniaturized robotics to identify suitable vessels for cannulation and robotically guide an attached needle toward the lumen center. The device demonstrated results comparable to or exceeding that of clinical standards, with a success rate of 87% on all participants ( ), a 97% success rate on nondifficult venous access participants ( ), and an average procedure time of s ( ). In the future, this device can be extended to other areas of vascular access such as IV catheterization, central venous access, dialysis, and arterial line placement.- 1 September 2019
- Published by World Scientific Pub Co Pte Ltd in TECHNOLOGY
- Vol. 07 (03n04) , 98-107
First-in-human evaluation of a hand-held automated venipuncture device for rapid venous blood draws
Obtaining venous access for blood sampling or intravenous (IV) fluid delivery is an essential first step in patient care. However, success rates rely heavily on clinician experience and patient physiology. Difficulties in obtaining venous access result in missed sticks and injury to patients, and typically require alternative access pathways and additional personnel that lengthen procedure times, thereby creating unnecessary costs to healthcare facilities. Here, we present the first-in-human assessment of an automated robotic venipuncture device designed to safely perform blood draws on peripheral forearm veins. The device combines ultrasound imaging and miniaturized robotics to identify suitable vessels for cannulation and robotically guide an attached needle toward the lumen center. The device demonstrated results comparable to or exceeding that of clinical standards, with a success rate of 87% on all participants ( ), a 97% success rate on nondifficult venous access participants ( ), and an average procedure time of s ( ). In the future, this device can be extended to other areas of vascular access such as IV catheterization, central venous access, dialysis, and arterial line placement.- 1 June 2018
- Published by World Scientific Pub Co Pte Ltd in TECHNOLOGY
- Vol. 06 (02) , 59-66
Automated end-to-end blood testing at the point-of-care: Integration of robotic phlebotomy with downstream sample processing
Diagnostic blood testing is the most commonly performed clinical procedure in the world, and influences the majority of medical decisions made in hospital and laboratory settings. However, manual blood draw success rates are dependent on clinician skill and patient physiology, and results are generated almost exclusively in centralized labs from large-volume samples using labor-intensive analytical techniques. This paper presents a medical device that enables end-to-end blood testing by performing blood draws and providing diagnostic results in a fully automated fashion at the point-of-care. The system couples an image-guided venipuncture robot, developed to address the challenges of routine venous access, with a centrifuge-based blood analyzer to obtain quantitative measurements of hematology. We first demonstrate a white blood cell assay on the analyzer, using a blood mimicking fluid spiked with fluorescent microbeads, where the area of the packed bead layer is correlated with the bead concentration. Next we perform experiments to evaluate the pumping efficiency of the sample handling module. Finally, studies are conducted on the integrated device — from blood draw to analysis — using blood vessel phantoms to assess the accuracy and repeatability of the resulting white blood cell assay.
- 1 June 2018
- Published by World Scientific Pub Co Pte Ltd in TECHNOLOGY
- Vol. 06 (02) , 59-66
Automated end-to-end blood testing at the point-of-care: Integration of robotic phlebotomy with downstream sample processing
Diagnostic blood testing is the most commonly performed clinical procedure in the world, and influences the majority of medical decisions made in hospital and laboratory settings. However, manual blood draw success rates are dependent on clinician skill and patient physiology, and results are generated almost exclusively in centralized labs from large-volume samples using labor-intensive analytical techniques. This paper presents a medical device that enables end-to-end blood testing by performing blood draws and providing diagnostic results in a fully automated fashion at the point-of-care. The system couples an image-guided venipuncture robot, developed to address the challenges of routine venous access, with a centrifuge-based blood analyzer to obtain quantitative measurements of hematology. We first demonstrate a white blood cell assay on the analyzer, using a blood mimicking fluid spiked with fluorescent microbeads, where the area of the packed bead layer is correlated with the bead concentration. Next we perform experiments to evaluate the pumping efficiency of the sample handling module. Finally, studies are conducted on the integrated device — from blood draw to analysis — using blood vessel phantoms to assess the accuracy and repeatability of the resulting white blood cell assay.
- Open Access
- 16 October 2017
- Published by ASME International in Journal of Medical Devices
- Vol. 11 (4) , 0410081-0410087
Design and Evaluation of a Robotic Device for Automated Tail Vein Cannulations in Rodent Models
Preclinical testing in rodent models is a ubiquitous part of modern biomedical research and commonly involves accessing the venous bloodstream for blood sampling and drug delivery. Manual tail vein cannulation is a time-consuming process and requires significant skill and training, particularly since improperly inserted needles can affect the experimental results and study outcomes. In this paper, we present a miniaturized, robotic medical device for automated, image-guided tail vein cannulations in rodent models. The device is composed of an actuated three degrees-of-freedom (DOFs) needle manipulator, three-dimensional (3D) near-infrared (NIR) stereo cameras, and an animal holding platform. Evaluating the system through a series of workspace simulations and free-space positioning tests, the device exhibited a sufficient work volume for the needle insertion task and submillimeter accuracy over the calibration targets. The results indicate that the device is capable of cannulating tail veins in rodent models as small as 0.3 mm in diameter, the smallest diameter vein required to target.
- 16 October 2017
- Published by ASME International in Journal of Medical Devices
- Vol. 11 (4) , 0410081-0410087
Open AccessDesign and Evaluation of a Robotic Device for Automated Tail Vein Cannulations in Rodent Models
Preclinical testing in rodent models is a ubiquitous part of modern biomedical research and commonly involves accessing the venous bloodstream for blood sampling and drug delivery. Manual tail vein cannulation is a time-consuming process and requires significant skill and training, particularly since improperly inserted needles can affect the experimental results and study outcomes. In this paper, we present a miniaturized, robotic medical device for automated, image-guided tail vein cannulations in rodent models. The device is composed of an actuated three degrees-of-freedom (DOFs) needle manipulator, three-dimensional (3D) near-infrared (NIR) stereo cameras, and an animal holding platform. Evaluating the system through a series of workspace simulations and free-space positioning tests, the device exhibited a sufficient work volume for the needle insertion task and submillimeter accuracy over the calibration targets. The results indicate that the device is capable of cannulating tail veins in rodent models as small as 0.3 mm in diameter, the smallest diameter vein required to target.