Raghumahanti Raghuveer

Benign paroxysmal positional vertigo (BPPV), particularly involving the posterior semicircular canal (PC-BPPV), is the most common peripheral vestibular di

Background: Abnormal cell growth that can multiply and transfer to other bodily parts is referred to as cancer. Chemotherapy is a standard treatment for cancer patients. During or after treatment, patients may have varying degrees of cognitive impairment caused by the drug, which can negatively impact their quality of life. Cognitive impairment brought on by chemotherapy is one of the most frequent side effects that occur both during and after chemotherapy. Cognitive effects after and during chemotherapy have not been addressed in patients. Objective: To evaluate the effectiveness of cognitive rehabilitation on cognition and quality of life in chemotherapy-induced cognitive impairment. Methods: In this Randomized Control Trial (RCT), 60 subjects with chemotherapy-induced cognitive impairments secondary to any cancer will be randomised into 2 groups by the sequentially numbered opaque sealed envelope approach. The cognitive functions will be measured as the outcome measures, which include all the recall strategies, executive function tasks, information processing speed, and attention. Both groups will receive intervention every day for 4 weeks. Wilcoxon signed the rank test for data analysis, and students paired the “t” test, which will be used to study within-group effects. Mann-Whitney U Test and students Unpaired “t” Test will be used to compare groups at pre-treatment and post-treatment. Results: As of November 2024, we will enrol 60 participants, and the data collection process will start from November 2024- November 2025. The expected results of the effect of cognitive rehabilitation on cognition and quality of life in chemotherapy-induced cognitive impairment in cancer patients will be significant, and the expected results will be published at the end week of November 2025. Conclusions: The study design is a framework to plan and test the feasibility of the intervention. The cognitive therapy will improve the cognition in chemotherapy-induced cognitive impairment patients. Trial Registration: Clinical Trials Registry India CTRI/2024/04/065805; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTAyNTE1&Enc=&userName= International Registered Report Identifier (IRRID): DERR1-10.2196/66011

This systematic review protocol introduces the rationale to investigate how well the Vojta approach works to improve respiratory function and lessen neuromuscular deficits in premature newborns. Innovative approaches like the Vojta technique may offer a possible therapeutic path for preterm newborns, who frequently suffer significant obstacles in their early development. We outline a rigorous methodology for this systematic review. A comprehensive search strategy will be implemented across various databases to identify relevant studies. This systematic review will encompass randomized controlled trials through electronic and manual searches. Electronic searches will be carried out in databases such as PubMed, Medline, Scopus, and Web of Science. The search will span articles published from 2000 to 2025; predefined eligibility criteria involve participants who were premature babies (those born before 37 weeks gestation). Exposure includes participants diagnosed with any other diagnosis that does not include NRDS. Outcome measures focus on oxygen saturation levels (SpO₂), arterial blood gas (ABG) analysis (e.g., PaO₂, PaCO₂, and pH), respiratory rate (breaths per minute), and lung compliance (static or dynamic) will all be used to quantify respiratory function. Two independent reviewers will conduct study selection, data extraction, and risk of bias assessment. The primary outcomes encompassing SpO₂, ABG, Ballard, and APGAR will be systematically analysed. Dissemination and ethics As no primary data will be collected, ethical approval is not required. The findings will be presented at relevant conferences and published in a peer-reviewed journal. Systematic review registration PROSPERO CRD420250643755.

Background: Neonatal respiratory distress syndrome (NRDS), a common and serious illness in preterm infants, is characterized by lung immaturity and inadequate surfactant production. Even though improvements in neonatal care have increased survival rates, optimizing supportive therapies such as physiotherapy is still essential to improve respiratory outcomes and overall recovery. Objective: This study aims to evaluate the effectiveness of physiotherapy therapies in enhancing respiratory function and clinical outcomes in neonates with NRDS. Methods: PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) guidelines will be followed for conducting a systematic review. Studies assessing the effects of physiotherapy therapies on newborns with NRDS, such as respiratory exercises, manual chest compressions, percussion, vibration, and postural drainage, high-frequency oscillation of the chest wall, cough stimulation, or suctioning will be included. A comprehensive search of electronic databases, including PubMed, Embase, CINAHL, and the Cochrane Library, to find pertinent observational studies, experimental studies, and randomized controlled trials, will be conducted. Important outcomes will be respiratory function metrics, oxygen saturation levels, length of mechanical ventilation, occurrence of problems, and overall newborn outcomes. Results: Exact numbers are not accessible at this time, as the review is hypothetical and has not yet been conducted. In order to inform clinical procedures and future studies, the results will contain data on respiratory improvement, intervention kinds, safety profiles, and the best times and frequencies for physical therapy in neonates with respiratory distress syndrome. Conclusions: This review will provide a comprehensive understanding of the role of physiotherapy in managing NRDS and its impact on clinical outcomes in neonates. The findings may guide clinical practice and inform future research on noninvasive strategies for improving neonatal respiratory care.

BACKGROUND Abnormal cell growth that can multiply and transfer to other bodily parts is referred to as cancer. Chemotherapy is a standard treatment for cancer patients. During or after treatment, patients may have varying degrees of cognitive impairment caused by the drug, which can negatively impact their quality of life. Cognitive impairment brought on by chemotherapy is one of the most frequent side effects that occur both during and after chemotherapy. Cognitive effects after and during chemotherapy have not been addressed in patients. OBJECTIVE To evaluate the effectiveness of cognitive rehabilitation on cognition and quality of life in chemotherapy-induced cognitive impairment. METHODS In this Randomized Control Trial (RCT), 60 subjects with chemotherapy-induced cognitive impairments secondary to any cancer will be randomised into 2 groups by the sequentially numbered opaque sealed envelope approach. The cognitive functions will be measured as the outcome measures, which include all the recall strategies, executive function tasks, information processing speed, and attention. Both groups will receive intervention every day for 4 weeks. Wilcoxon signed the rank test for data analysis, and students paired the “t” test, which will be used to study within-group effects. Mann-Whitney U Test and students Unpaired “t” Test will be used to compare groups at pre-treatment and post-treatment. RESULTS As of November 2024, we will enrol 60 participants, and the data collection process will start from November 2024- November 2025. The expected results of the effect of cognitive rehabilitation on cognition and quality of life in chemotherapy-induced cognitive impairment in cancer patients will be significant, and the expected results will be published at the end week of November 2025. CONCLUSIONS The study design is a framework to plan and test the feasibility of the intervention. The cognitive therapy will improve the cognition in chemotherapy-induced cognitive impairment patients. CLINICALTRIAL Clinical Trials Registry India CTRI/2024/04/065805; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTAyNTE1&Enc=&userName= INTERNATIONAL REGISTERED REPORT DERR1-10.2196/66011

Introduction Hemiplegia is the common term used to describe a multitude of clinical problems associated with a stroke. Hemiplegic stroke accounts for 70-85% of all first strokes. Trunk stability is impaired due to hypertonia and weakness in hemiplegia. Impaired trunk control leads to gait and postural abnormalities which if left untreated causes permanent disability in hemiplegics. Objective To investigate the scope of research on the benefits of explicit training using Neurodevelopmental Therapy (NDT) for enhancing tone and postural control in subjects with hemiplegic stroke. Methods In order to adhere to established protocols of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, the systematic review will be carried out to find pertinent studies published up to the search date, and a thorough search strategy will be applied across popular electronic databases including PubMed/Medline, Scopus, and Cochrane Library. This systematic review methodology has been registered in PROSPERO for rigorous and transparent dissemination of study search, synthesis, and analysis. Discussion As the motor impairments due to abnormal tone and postural impairment in hemiplegic stroke substantially impact a stroke survivor’s quality of life, this study will provide a thorough and methodical approach to synthesize and report the merits and demerits on the effectiveness of NDT in enhancing tone and postural control, considering the potential variability in interventions and outcomes, and the methodological rigor of particular studies. The review also intends to provide significant insights for clinicians, researchers, and policymakers by critically analysing and summarizing the present state of research in this domain. This will facilitate evidence-based decision-making in rehabilitation techniques for patients with hemiplegic stroke. Systematic Review Registration number CRD42023476137

Introduction Bronchopulmonary dysplasia (BPD) is a common chronic lung disease that affects premature infants and is characterized by disrupted alveolar and vascular development. Pulmonary complications significantly affect morbidity and mortality rates in neonates with BPD. Aim This systematic review aimed to outline a protocol for investigating the effects of pulmonary complications in neonates diagnosed with BPD. Methods A comprehensive search strategy will be implemented across electronic databases, including PubMed, MEDLINE, Embase, and Cochrane Library. Eligible studies will include primary research articles reporting pulmonary complications, such as pulmonary hypertension, respiratory infections, ventilator-associated events, and airway abnormalities among neonates diagnosed with BPD. Two independent reviewers screened the titles, abstracts, and full text of the identified articles for eligibility. Data extraction will be conducted using a predefined form, including study characteristics, participant demographics, types of pulmonary complications, and relevant outcomes. The methodological quality of the included studies will be assessed using appropriate tools, such as the Cochrane Risk of Bias Tool for randomized controlled trials. Outcome measures The primary outcomes of interest will include the prevalence and incidence of pulmonary complications among neonates diagnosed with BPD. Secondary outcomes will encompass the impact of pulmonary complications on clinical outcomes, such as respiratory morbidity, mortality rates, length of hospital stay, and neurodevelopmental outcomes. Narrative synthesis will be employed to summarize the findings of the included studies, and where applicable, a meta-analysis will be conducted to quantify the effects of pulmonary complications on neonatal outcomes. Discussion This systematic review protocol outlines a rigorous methodology for investigating the effects of pulmonary complications in neonates with BPD. The findings of this review will provide valuable insights into the burden of pulmonary complications in this vulnerable population, and inform clinical practice and future research endeavors aimed at improving the care and management of neonates with BPD. Systematic Review Registration no. CRD42024524133

Background Neonatal Respiratory Distress Syndrome (NRDS) remains a significant challenge in neonatal care, often leading to respiratory compromise and neuromuscular dysfunction. While advances in medical management have improved outcomes, adjunctive therapies such as physical rehabilitation offer potential benefits yet require further investigation. This protocol outlines a randomized controlled trial aiming to evaluate the effect of Physical Rehabilitation using Oro Motor Stimulation, Manual Airway Clearance Technique, Positioning, Tactile, and Kinesthetic Stimulation (PROMPT) protocol on respiratory and neuromuscular function in neonates with NRDS. Methods The trial will include 38 neonates diagnosed with NRDS, randomly allocated into two groups: the intervention group receiving the PROMPT protocol alongside standard care, and the control group receiving standard care alone. The PROMPT protocol comprises a comprehensive approach targeting oromotor stimulation, manual airway clearance technique, optimal positioning, and tactile/kinesthetic stimulation. Outcome measures Primary outcomes will focus on respiratory parameters such as oxygenation index, ventilatory support requirements, and neuromuscular function assessed through muscle tone and reflexes. Secondary outcomes will encompass length of hospital stay, incidence of complications, and neurodevelopmental outcomes at follow-up. Results Data analysis will employ appropriate statistical methods to compare outcomes between the intervention and control groups, with adjustments for potential confounders. Ethical approval has been obtained, and informed consent will be obtained from parents or legal guardians before enrolment. Conclusion This trial protocol aims to provide valuable insights into the efficacy and safety of the PROMPT protocol as a rehabilitative intervention for NRDS. The findings may inform future clinical practice and contribute to optimizing care strategies for neonates with NRDS, ultimately improving their short- and long-term outcomes. Registration CTRI/2024/03/064911

Developmental Coordination Disorder (DCD) significantly impacts motor coordination and hand-eye coordination in children, affecting their daily activities and academic performance. This study aims to investigate the efficacy of Physical Rehabilitation utilizing the Sensory Stimulation and Developmental Vestibular (SSDV) protocol in improving motor coordination and hand-eye coordination in children diagnosed with DCD. Children diagnosed with DCD will be recruited and randomly allocated to either the intervention group receiving Physical Rehabilitation using the SSDV protocol or the control group receiving standard care. The intervention will involve a structured program incorporating sensory stimulation and developmental vestibular activities tailored to the individual needs of participants. Motor coordination and hand-eye coordination will be assessed using standardized measures such as the Movement Assessment Battery for Children (MABC) and the Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery VMI). Assessments will be conducted at baseline, post-intervention, and follow-up time points. This randomized controlled trial seeks to evaluate the effectiveness of Physical Rehabilitation using the SSDV protocol in enhancing motor coordination and hand-eye coordination in children with DCD. By employing standardized measures, this study aims to provide objective insights into the impact of the intervention. Findings from this trial may contribute to the development of evidence-based interventions for children with DCD, potentially improving their motor skills and overall functioning in daily life and academic settings. Registration: CTRI/2024/03/064467