Awadhesh Pandit
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Awadhesh Pandit has a total of 16 co-authors. Here are the top co-authors by number of shared publications:
- Aamir Khan
Signal Transduction Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
1 shared publication - Arnab Mukhopadhyay
Molecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
1 shared publication - Avinash Bajaj
Laboratory of Tumour Immune Microenvironment (TIME), Regional Centre for Biotechnology, 3(rd) Milestone Faridabad Gurgaon Expressway, Faridabad 121001, India
1 shared publication - Ekjot Kaur
MRC Laboratory of Medical Sciences, London, United Kingdom
1 shared publication - Himanshi Agarwal
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
1 shared publication - Isabelle Gross
University of Strasbourg, INSERM UMR_S 1113, "SMART" Laboratory, Strasbourg, France; INSERM, UMR 1260, CRBS, Regenerative Nanomedicine, "HERIIT" Laboratory, University of Strasbourg, Strasbourg, France
1 shared publication
Latest Publications
- Open Access
- 1 August 2021
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 134 (15)
CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors
Meta-analysis of transcripts in colon adenocarcinoma patient tissues led to the identification of a DNA damage responsive miR signature called DNA damage sensitive miRs (DDSMs). DDSMs were experimentally validated in the cancerous colon tissues obtained from an independent cohort of colon cancer patients and in multiple cellular systems with high levels of endogenous DNA damage. All the tested DDSMs were transcriptionally upregulated by a common intestine-specific transcription factor, CDX2. Reciprocally, DDSMs were repressed via the recruitment of HDAC1/2-containing complexes onto the CDX2 promoter. These miRs downregulated multiple key targets in the DNA damage response (DDR) pathway, namely BRCA1, ATM, Chk1 (also known as CHEK1) and RNF8. CDX2 directly regulated the DDSMs, which led to increased tumor volume and metastasis in multiple preclinical models. In colon cancer patient tissues, the DDSMs negatively correlated with BRCA1 levels, were associated with decreased probability of survival and thereby could be used as a prognostic biomarker. This article has an associated First Person interview with the first author of the paper.
- 1 August 2021
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 134 (15)
Open AccessCDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors
Meta-analysis of transcripts in colon adenocarcinoma patient tissues led to the identification of a DNA damage responsive miR signature called DNA damage sensitive miRs (DDSMs). DDSMs were experimentally validated in the cancerous colon tissues obtained from an independent cohort of colon cancer patients and in multiple cellular systems with high levels of endogenous DNA damage. All the tested DDSMs were transcriptionally upregulated by a common intestine-specific transcription factor, CDX2. Reciprocally, DDSMs were repressed via the recruitment of HDAC1/2-containing complexes onto the CDX2 promoter. These miRs downregulated multiple key targets in the DNA damage response (DDR) pathway, namely BRCA1, ATM, Chk1 (also known as CHEK1) and RNF8. CDX2 directly regulated the DDSMs, which led to increased tumor volume and metastasis in multiple preclinical models. In colon cancer patient tissues, the DDSMs negatively correlated with BRCA1 levels, were associated with decreased probability of survival and thereby could be used as a prognostic biomarker. This article has an associated First Person interview with the first author of the paper.