André Tarsis Domiciano
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
André Tarsis Domiciano has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- Ana Calheiros de Carvalho
Programa de Pós-Graduação em Biologia Química, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema 09972-270, Brazil
1 shared publication - Cauê Santos Lima
Pós-Graduado em Ciências Instituição Universidade Federal de São Paulo (Unifesp) Endereço São Paulo São Paulo Brasil
1 shared publication - Edgar Julian Paredes-Gamero
Laboratory of Molecular Biology, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil
1 shared publication - Heron Fernandes Vieira Torquato
Laboratory of Molecular Biology and Cell Cultures, Faculty of Pharmaceutical Sciences, Food and Nutrition (FACFAN)
1 shared publication - Lucas Magalhães de Abreu
Universidade Federal de Viçosa
1 shared publication - Lívia Soman de Medeiros
Institute of Environmental, Chemical and Pharmaceutical Sciences, Department of Chemistry, Federal University of Sao Paulo, Diadema, 09972-270, Brazil
1 shared publication
Latest Publications
- Open Access
- 23 December 2022
- Published by MDPI AG in Metabolites
- Vol. 13 (1) , 23
Chemodiversity and Anti-Leukemia Effect of Metabolites from Penicillium setosum CMLD 18
Penicillium setosum represents a Penicillium species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of P. setosum CMLD18, a strain isolated from Swinglea glutinosa (Rutaceae). HRMS-MS guided dereplication strategies and anti-leukemia assays conducted the isolation and characterization of six compounds after several chromatographic procedures: 2-chloroemodic acid (2), 2-chloro-1,3,8-trihydroxy-6- (hydroxymethyl)-anthraquinone (7), 7-chloroemodin (8), bisdethiobis(methylthio)acetylaranotine (9), fellutanine C (10), and 4-methyl-5,6-diihydro-2H-pyran-2-one (15). From the assayed metabolites, (10) induced cellular death against Kasumi-1, a human leukemia cell line, as well as good selectivity for it, displaying promising cytotoxic activity. Here, the correct NMR signal assignments for (9) are also described. Therefore, this work highlights more detailed knowledge about the P. setosum chemical profile as well as its biological potential, offering prospects for obtaining natural products with anti-leukemia capabilities.
- 23 December 2022
- Published by MDPI AG in Metabolites
- Vol. 13 (1) , 23
Open AccessChemodiversity and Anti-Leukemia Effect of Metabolites from Penicillium setosum CMLD 18
Penicillium setosum represents a Penicillium species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of P. setosum CMLD18, a strain isolated from Swinglea glutinosa (Rutaceae). HRMS-MS guided dereplication strategies and anti-leukemia assays conducted the isolation and characterization of six compounds after several chromatographic procedures: 2-chloroemodic acid (2), 2-chloro-1,3,8-trihydroxy-6- (hydroxymethyl)-anthraquinone (7), 7-chloroemodin (8), bisdethiobis(methylthio)acetylaranotine (9), fellutanine C (10), and 4-methyl-5,6-diihydro-2H-pyran-2-one (15). From the assayed metabolites, (10) induced cellular death against Kasumi-1, a human leukemia cell line, as well as good selectivity for it, displaying promising cytotoxic activity. Here, the correct NMR signal assignments for (9) are also described. Therefore, this work highlights more detailed knowledge about the P. setosum chemical profile as well as its biological potential, offering prospects for obtaining natural products with anti-leukemia capabilities.