Paul N. Devine
Research Subjects
Research Interests
Paul N. Devine has a total of 23 co-authors. Here are the top co-authors by number of shared publications:
- Anna Fryszkowska
Merck & Co., Inc
1 shared publication - Christopher C. Nawrat
Merck & Co. Inc
1 shared publication Claire M. Ouimet
Merck & Co., Inc
1 shared publication- Da Duan
Codexis (United States)
1 shared publication - Deeptak Verma
Merck & Co
1 shared publication - Eric L. Margelefsky
Process Research & Development
1 shared publication
Latest Publications
- Open Access
- 26 October 2023
- Published by American Chemical Society (ACS) in ChemRxiv
Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir
Biocatalytic oxidations have the potential to address many synthetic chemistry challenges, enabling the selective synthesis of chiral intermediates such as carbonyl compounds, alcohols, or amines. The use of oxygen-dependent enzymes can dramatically reduce the environmental footprint of redox transformations at manufacturing scale. Here, as part of the biocatalytic cascade to an anti-HIV investigational drug islatravir 1, we describe the development of an aerobic oxidation process delivering (R)-ethynylglyceraldehyde 3-phosphate 3 using an evolved galactose oxidase enzyme. Integrated enzyme and reaction engineering were critical for achieving a robust, high-yielding oxidation performed at pilot plant scale (>20 kg, 90% yield).
- 26 October 2023
- Published by American Chemical Society (ACS) in ChemRxiv
Open AccessDevelopment of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir
Biocatalytic oxidations have the potential to address many synthetic chemistry challenges, enabling the selective synthesis of chiral intermediates such as carbonyl compounds, alcohols, or amines. The use of oxygen-dependent enzymes can dramatically reduce the environmental footprint of redox transformations at manufacturing scale. Here, as part of the biocatalytic cascade to an anti-HIV investigational drug islatravir 1, we describe the development of an aerobic oxidation process delivering (R)-ethynylglyceraldehyde 3-phosphate 3 using an evolved galactose oxidase enzyme. Integrated enzyme and reaction engineering were critical for achieving a robust, high-yielding oxidation performed at pilot plant scale (>20 kg, 90% yield).