Thomas Laumont
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Thomas Laumont has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Jean Luc Pasquier
Department of Cardiology, University Hospital of Montpellier , Montpellier
1 shared publication - July Beghian
Phymedexp, Université de Montpellier, Inserm, CNRS, CHRU de Montpellier, 34295 Montpellier, France
1 shared publication - Laura Sofia Cardelli
Cardiology Department, Ospedale Maggiore Carlo Alberto Pizzardi, Bologna, Emilia-Romagna, Italy
1 shared publication - Maida Cardoso
UMR 5221, University Montpellier, CNRS, 34095 Montpellier, France
1 shared publication - Marylène Bacle
RAM-PTNIM, Medical School of Nîmes, Montpellier University, 34090 Montpellier, France
1 shared publication - Mathieu Granier
University Hospital Montpellier, France (M.G., L.P.).
1 shared publication
Latest Publications
- Open Access
- 30 August 2024
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 13 (17) , 5153
Radiofrequency Lesion in the Atrial Wall: How Variable Is It? 9.4 Tesla MRI Analysis of Radiofrequency Lesion Volume in a Swine Model
Background/Objectives: Most data on radiofrequency (RF) effects come from ex vivo or in vitro studies that quantify lesions using width and/or depth, while electrophysiologists use manufacturers’ indirect indices. The objective of this study was to evaluate RF lesion volume by high-resolution MRI of excised lesions in an in vivo porcine model, comparing a low-energy long-duration (LE) (20 W, 50 s) RF application strategy with a high-energy short-duration (HE) (50 W, 20 s) one. Methods: Eighteen piglets were divided into LE (n = 9) and HE groups (n = 9). RF applications were performed at four locations in both atria. Animals were sacrificed after 5–7 days, and RF lesion specimens were excised, fixed, and analyzed by 9.4 Tesla MRI. RF lesion volume, variability (variance), depth, and any extracardiac lesions were compared between the groups. Results: Seventy RF applications were performed (36 LE, 34 HE). MRI analyzed 26 LE and 28 HE samples. The HE group showed 35% higher volume than the LE group (100.2 mm3 (±81.2) in LE vs. 178.3 mm3 (±163.7) in HE, p = 0.033). RF volume variance was 6.6 mm3 in LE and 40.3 mm3 in HE. The HE group had more complications (seven vs. zero, p = 0.02) and extracardiac lesions (18 vs. 14, p = 0.613). Conclusions: There was large and unpredictable variability in RF injury on the atrial wall, even under controlled conditions, which could explain arrhythmia recurrences. The greatest lesion variability was found during HE applications. The dose/effect relationship of RF needs careful study for treating cardiac arrhythmias.
- 30 August 2024
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 13 (17) , 5153
Open AccessRadiofrequency Lesion in the Atrial Wall: How Variable Is It? 9.4 Tesla MRI Analysis of Radiofrequency Lesion Volume in a Swine Model
Background/Objectives: Most data on radiofrequency (RF) effects come from ex vivo or in vitro studies that quantify lesions using width and/or depth, while electrophysiologists use manufacturers’ indirect indices. The objective of this study was to evaluate RF lesion volume by high-resolution MRI of excised lesions in an in vivo porcine model, comparing a low-energy long-duration (LE) (20 W, 50 s) RF application strategy with a high-energy short-duration (HE) (50 W, 20 s) one. Methods: Eighteen piglets were divided into LE (n = 9) and HE groups (n = 9). RF applications were performed at four locations in both atria. Animals were sacrificed after 5–7 days, and RF lesion specimens were excised, fixed, and analyzed by 9.4 Tesla MRI. RF lesion volume, variability (variance), depth, and any extracardiac lesions were compared between the groups. Results: Seventy RF applications were performed (36 LE, 34 HE). MRI analyzed 26 LE and 28 HE samples. The HE group showed 35% higher volume than the LE group (100.2 mm3 (±81.2) in LE vs. 178.3 mm3 (±163.7) in HE, p = 0.033). RF volume variance was 6.6 mm3 in LE and 40.3 mm3 in HE. The HE group had more complications (seven vs. zero, p = 0.02) and extracardiac lesions (18 vs. 14, p = 0.613). Conclusions: There was large and unpredictable variability in RF injury on the atrial wall, even under controlled conditions, which could explain arrhythmia recurrences. The greatest lesion variability was found during HE applications. The dose/effect relationship of RF needs careful study for treating cardiac arrhythmias.