Patricia Deng
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Patricia Deng has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- David Gorelick
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel
1 shared publication - Eyal Rozenfeld
Department of Physiology and Pharmacology, Gray Faculty of Medical and Health, Sciences Tel Aviv University Tel Aviv Israel
1 shared publication - Galit Shohat-Ophir
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University
1 shared publication Hadar Pozeilov
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel
1 shared publicationHila Zak
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel
1 shared publication- Jin Billy Li
Department of Genetics, Stanford University, Stanford, USA
1 shared publication
Latest Publications
- 6 September 2024
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 10 (36) , eadi9101
A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in Drosophila
A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA molecules to inosines, which are recognized as guanosines by cellular machinery. Despite the vast number of editing sites observed across the animal kingdom, pinpointing critical sites and understanding their in vivo functions remains challenging. Here, we study the function of an evolutionary conserved editing site in Drosophila , located in glutamate-gated chloride channel ( GluCl α). Our findings reveal that flies lacking editing at this site exhibit reduced olfactory responses to odors and impaired pheromone-dependent social interactions. Moreover, we demonstrate that editing of this site is crucial for the proper processing of olfactory information in projection neurons. Our results highlight the value of using evolutionary conservation as a criterion for identifying editing events with potential functional significance and paves the way for elucidating the intricate link between RNA modification, neuronal physiology, and behavior.
- 6 September 2024
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 10 (36) , eadi9101
A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in Drosophila
A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA molecules to inosines, which are recognized as guanosines by cellular machinery. Despite the vast number of editing sites observed across the animal kingdom, pinpointing critical sites and understanding their in vivo functions remains challenging. Here, we study the function of an evolutionary conserved editing site in Drosophila , located in glutamate-gated chloride channel ( GluCl α). Our findings reveal that flies lacking editing at this site exhibit reduced olfactory responses to odors and impaired pheromone-dependent social interactions. Moreover, we demonstrate that editing of this site is crucial for the proper processing of olfactory information in projection neurons. Our results highlight the value of using evolutionary conservation as a criterion for identifying editing events with potential functional significance and paves the way for elucidating the intricate link between RNA modification, neuronal physiology, and behavior.