Guixiang Wang

Background/Aims: Type 2 diabetes mellitus (T2DM) is increasingly recognized as a factor that may influence the course of acute pancreatitis (AP), but its independent associations with severity and mortality remain uncertain. The study investigated the independent association of preexisting T2DM with disease severity and in-hospital mortality in individuals with AP. Materials and Methods: This multicenter retrospective cohort study included 4458 patients with AP from 3 medical centers. Patients were categorized into T2DM (n = 711) and non-T2DM groups (n = 3747). Demographic and clinical data were collected. Multivariable logistic regression analysis was used to evaluate the associations of T2DM with disease severity and in-hospital mortality after adjustment for potential confounders. Stabilized inverse probability of treatment weighting (sIPTW) analyses were performed to assess the robustness of the results. Results: Compared with the non-T2DM group, the T2DM group was older and had a significantly higher proportion of males, and higher prevalences of hypertension and chronic kidney disease. In multivariable analysis, T2DM was independently associated with increased disease severity (OR = 1.42, 95% CI: 1.19-1.69) but not with in-hospital mortality (OR = 1.14, 95% CI: 0.61-2.02). The sIPTW analysis yielded consistent findings, with T2DM remaining independently associated with increased disease severity but not with in-hospital mortality. Conclusion: Preexisting T2DM is independently associated with increased disease severity in patients with AP but not with in-hospital mortality. Cite this article as: Wu B, Ju H, He C, Wang W, Wang G. Type 2 diabetes increases severity but not mortality in acute pancreatitis: A large multicenter analysis. Turk J Gastroenterol. Published online September 07, 2026. doi: 10.5152/tjg.2026.26159.

Background: The impact of prolonged surgical waiting time (SWT) on the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains controversial. This study aimed to explore the impact of prolonged SWT on PDAC-specific mortality (PSM). Methods: The data of patients with stage I–II primary PDAC who received radical resection were obtained from the Surveillance, Epidemiology, and End Results database. The trends analysis was performed to explore the association between the year of diagnosis and SWT. The Fine-Gray multivariate competing risk analysis was performed to determine the impact of prolonged SWT on PSM. Results: A total of 8,562 patients were included in this study. In general, SWT had an increasing trend from 2007 to 2017. Multivariate survival analysis showed that SWT of ≥1 month and Conclusions: We found that prolonged SWT does not affect or worsen PSM of patients with stage I–II PDAC who underwent successful radical resection. Our findings offer useful evidence about the association between prolonged SWT and PSM, which may relieve patients’ and doctors’ psychological stress related to delayed surgery to some extent.