Le Kang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Le Kang has a total of 23 co-authors. Here are the top co-authors by number of shared publications:
- Dequn Wu
Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai 201620, China
2 shared publications - Chenggong Zhang
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Shanghai Frontiers Science Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China
1 shared publication - Chuandong Wang
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
1 shared publication - Hao Liu
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Shanghai Frontiers Science Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China
1 shared publication - Huipeng Wang
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Shanghai Frontiers Science Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China
1 shared publication - Jianxiang Li
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Shanghai Frontiers Science Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China
1 shared publication
Latest Publications
- Open Access
- 29 July 2026
- Published by Springer Nature in Journal of Nanobiotechnology
- Vol. 24 (1) , 829
ROS-responsive injectable hydrogel enables controlled release of human adipose tissue–derived extracellular vesicles for multifaceted osteoarthritis therapy
- 29 July 2026
- Published by Springer Nature in Journal of Nanobiotechnology
- Vol. 24 (1) , 829
Open AccessROS-responsive injectable hydrogel enables controlled release of human adipose tissue–derived extracellular vesicles for multifaceted osteoarthritis therapy
- 27 January 2026
- Published by Elsevier in Carbohydrate Polymers
- Vol. 379, 124977
Modular alginate-based hydrogels embedding multilayer nanofibers: A synergistic strategy for hemostasis, antibacterial, and immunomodulatory therapy
- 27 January 2026
- Published by Elsevier in Carbohydrate Polymers
- Vol. 379, 124977
Modular alginate-based hydrogels embedding multilayer nanofibers: A synergistic strategy for hemostasis, antibacterial, and immunomodulatory therapy
- Open Access
Surface-Localized Crosslinked MEW PCL–Hydrogel Scaffolds with Tunable Porosity for Enhanced Cell Adhesion and Viability
Hydrogel is widely used as a scaffolding material for tissue engineering due to its excellent cytocompatibility and potential for biofunctionalization. However, its poor mechanical property limits its further application. Fabrication of fiber-reinforced hydrogel composite scaffolds has emerged as a solution to overcome this problem. However, existing strategies usually produce nonporous composite scaffolds, where the interfiber pores are completely filled with hydrogel. This design can hinder oxygen and nutrient exchange between seeded cells and the culture medium, thereby limiting cell invasion and colonization within the scaffold. In this study, sodium alginate (SA) hydrogel was exclusively grafted onto the surface of the constituent fibers of the melt electrowritten scaffold while preserving the porous structure. The grafted hydrogel amount and pore size were precisely controlled by adjusting the SA concentration and the crosslinking ratio (SA: CaCl2). Experimental results demonstrated that the porous composite scaffolds exhibited superior swelling capacity, degradation ratio, mechanical properties, and biocompatibility. Notably, at an SA concentration of 0.5% and a crosslinking ratio of 2:1, the porous composite scaffold achieved optimal cell adhesion and viability. This study highlights the critical importance of preserving porous structures in composite scaffolds for tissue-engineering applications.
Open AccessSurface-Localized Crosslinked MEW PCL–Hydrogel Scaffolds with Tunable Porosity for Enhanced Cell Adhesion and Viability
Hydrogel is widely used as a scaffolding material for tissue engineering due to its excellent cytocompatibility and potential for biofunctionalization. However, its poor mechanical property limits its further application. Fabrication of fiber-reinforced hydrogel composite scaffolds has emerged as a solution to overcome this problem. However, existing strategies usually produce nonporous composite scaffolds, where the interfiber pores are completely filled with hydrogel. This design can hinder oxygen and nutrient exchange between seeded cells and the culture medium, thereby limiting cell invasion and colonization within the scaffold. In this study, sodium alginate (SA) hydrogel was exclusively grafted onto the surface of the constituent fibers of the melt electrowritten scaffold while preserving the porous structure. The grafted hydrogel amount and pore size were precisely controlled by adjusting the SA concentration and the crosslinking ratio (SA: CaCl2). Experimental results demonstrated that the porous composite scaffolds exhibited superior swelling capacity, degradation ratio, mechanical properties, and biocompatibility. Notably, at an SA concentration of 0.5% and a crosslinking ratio of 2:1, the porous composite scaffold achieved optimal cell adhesion and viability. This study highlights the critical importance of preserving porous structures in composite scaffolds for tissue-engineering applications.