Dean Basic
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Dean Basic has a total of 20 co-authors. Here are the top co-authors by number of shared publications:
Alexander Walsh
Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland
1 shared publication- Alon Chen
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel
1 shared publication Ambika Periyakaruppiah
Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland
1 shared publicationArie Maeve Brueckner
Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland
1 shared publication- Esmi Lau Zajaczkowski
Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland
1 shared publication - Hao Gong
Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland
1 shared publication
Latest Publications
- Open Access
- 28 February 2024
- Published by Society for Neuroscience in The Journal of Neuroscience
- Vol. 44 (15)
DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation. One-Sentence Summary: G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory.
- 28 February 2024
- Published by Society for Neuroscience in The Journal of Neuroscience
- Vol. 44 (15)
Open AccessDNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation. One-Sentence Summary: G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory.