A.A. Tkachenko

The aim is to describe the connective tissue mechanism of lower third molar eruption in normal conditions and in cases of connective tissue dysplasia, to develop and test a technology to support medical decision-making in assessing the risk of lower third molar eruption diseases and purulent-septic complications. Materials and Methods. The study involved 327 women who underwent clinical, radiological, microscopic, morphological, and biochemical examinations to determine the presence and degree of connective tissue dysplasia and to develop a description of the mechanism of lower third molar eruption. For clinical testing of the decision support technology, two groups of patients were selected: those with CTD (n=20) and those without CTD (n=20) diagnosed with acute pericoronitis, in whom the presence of clinical symptoms was assessed in the early postoperative period. Results. A conceptual description of the mechanism of eruption of lower third molars in connective tissue dysplasia was provided, which made it possible to develop and test a technology for supporting medical decision-making and criteria for establishing the risk of purulent-septic complications in cases of impaired eruption of lower third molars. The application of medical decision-making technology in the clinic for patients with connective tissue dysplasia made it possible to reduce pain syndrome by 1-2 days, general symptoms of intoxication by 3-4 days, and local manifestations by 5-6 days, which in many respects achieved a clinical effect similar to that in the control group (examined without CTD) in many respects, as well as preventing the development of purulent-septic complications in the early postoperative period. Conclusions. The developed mechanisms and technologies are aimed at understanding the causes of impaired eruption of lower third molars and provide a methodology for managing patients with this condition for timely diagnosis and prevention of purulent-septic complications.