Jonna Mercado
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Jonna Mercado has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Abhishek Kumar Mariswamy Arun Kumar
Department of Internal Medicine, Wright State University, Dayton, OH 45458, USA
1 shared publication - Antony Arumairaj
Woodhull Medical Center, NYU Langone, Brooklyn, NY 11206, USA
1 shared publication - Dili Dhanani
Department of Anesthesiology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
1 shared publication - Divya Korpu
Mayo Clinic Health System, Eau Claire, WI 54703, USA
1 shared publication - Jayesh Mittal
Asante Rogue Regional Medical Center, Medford, OR 97504, USA
1 shared publication - Jyothika Venkataswamy Reddy
Chamarajanagar Institute of Medical Sciences, Chamarajanagar 571313, Karnataka, India
1 shared publication
Latest Publications
- Open Access
- 24 July 2026
- Published by MDPI AG in Preprints.org
Clinical Outcomes and Hospital Resource Utilization Among Patients with Septic Shock and COVID-19 Infection: Insights from United States National Inpatient Sample Analysis 2020–2022
Coronavirus disease 2019 (COVID-19) causes a hyperinflammatory state, endothelial injury, microvascular thrombosis and myocardial dysfunction, which may lead to worsening circulatory failure in septic shock. Using a large National Inpatient Sample (NIS) database from 2020 to 2022, we aimed to compare in-hospital mortality, need for mechanical ventilation, acute kidney injury (AKI), need for renal replacement therapy (RRT), cardiac arrest, acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO), tracheostomy, acute liver failure, disseminated intravascular coagulation (DIC), hospital length of stay (LOS), and total hospital charges in septic shock hospitalizations with and without COVID-19. A total of 2,175,619 adult septic shock hospitalizations were identified, of which 378,635 (17.4%) had COVID-19 infection. Hospitalizations with COVID-19 had significantly higher mortality (60.3% vs. 32.2%; aOR 3.43, 95% CI 3.35–3.50), increased need for non-invasive ventilation, invasive ventilation, and higher incidence of AKI, RRT, cardiac arrest, ARDS, ECMO use, and tracheostomy. Additionally, hospital LOS and total hospital charges were also significantly higher in hospitalizations with COVID-19. There was no significant difference in acute liver failure or DIC. In conclusion, COVID-19 infection was independently associated with worse outcomes and increased hospital resource utilization in adult septic shock hospitalizations.
- 24 July 2026
- Published by MDPI AG in Preprints.org
Open AccessClinical Outcomes and Hospital Resource Utilization Among Patients with Septic Shock and COVID-19 Infection: Insights from United States National Inpatient Sample Analysis 2020–2022
Coronavirus disease 2019 (COVID-19) causes a hyperinflammatory state, endothelial injury, microvascular thrombosis and myocardial dysfunction, which may lead to worsening circulatory failure in septic shock. Using a large National Inpatient Sample (NIS) database from 2020 to 2022, we aimed to compare in-hospital mortality, need for mechanical ventilation, acute kidney injury (AKI), need for renal replacement therapy (RRT), cardiac arrest, acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO), tracheostomy, acute liver failure, disseminated intravascular coagulation (DIC), hospital length of stay (LOS), and total hospital charges in septic shock hospitalizations with and without COVID-19. A total of 2,175,619 adult septic shock hospitalizations were identified, of which 378,635 (17.4%) had COVID-19 infection. Hospitalizations with COVID-19 had significantly higher mortality (60.3% vs. 32.2%; aOR 3.43, 95% CI 3.35–3.50), increased need for non-invasive ventilation, invasive ventilation, and higher incidence of AKI, RRT, cardiac arrest, ARDS, ECMO use, and tracheostomy. Additionally, hospital LOS and total hospital charges were also significantly higher in hospitalizations with COVID-19. There was no significant difference in acute liver failure or DIC. In conclusion, COVID-19 infection was independently associated with worse outcomes and increased hospital resource utilization in adult septic shock hospitalizations.