Demet Inci
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Demet Inci has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Ahmet Cingöz
School of Medicine, Koç University, 34450 Istanbul, Turkey
1 shared publication - Arda Inanc
Boğaziçi University
1 shared publication - Bora Akgun
Boğaziçi University
1 shared publication - Tuna Pesen
Department of Physics, Boğaziçi University, 34342, Beşiktaş, İstanbul, Türkiye
1 shared publication
Latest Publications
- Open Access
Coupling Raman Spectroscopy and Acoustic Microscopy to Characterize Glioblastoma Resistance
Therapy resistance in glioblastoma is usually described in genetic or metabolic terms. Here we ask whether it also has a measurable biophysical form. Combining Raman spectroscopy with scanning acoustic microscopy on TRAIL-sensitive and TRAIL-resistant glioblastoma cells, we find that resistance carries both a biochemical and a mechanical signature: the resistant cells differ at protein, lipid and nucleic-acid bands, contain 4.1-fold more neutral lipid, and hold a high acoustic impedance that does not change when the drug is applied, while sensitive cells stiffen as they die. Because acoustic impedance is an absolute quantity and neither measurement requires a label, the approach offers a route to recognising resistant populations from their physical state alone.
Open AccessCoupling Raman Spectroscopy and Acoustic Microscopy to Characterize Glioblastoma Resistance
Therapy resistance in glioblastoma is usually described in genetic or metabolic terms. Here we ask whether it also has a measurable biophysical form. Combining Raman spectroscopy with scanning acoustic microscopy on TRAIL-sensitive and TRAIL-resistant glioblastoma cells, we find that resistance carries both a biochemical and a mechanical signature: the resistant cells differ at protein, lipid and nucleic-acid bands, contain 4.1-fold more neutral lipid, and hold a high acoustic impedance that does not change when the drug is applied, while sensitive cells stiffen as they die. Because acoustic impedance is an absolute quantity and neither measurement requires a label, the approach offers a route to recognising resistant populations from their physical state alone.