Synthesis of Substituted Imidazo[1,2‐a]pyridines, Imidazo[1,2‐a]pyrazines and Imidazo[1,2‐b]pyridazines by Multicomponent Reactions Using Green Solvents
Open Access
- 26 April 2025
- journal article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 28 (26)
Abstract
Herein, the synthesis of imidazo[1,2‐a]pyridines, imidazo[1,2‐a]pyrazines and imidazo[1,2‐b]pyridazines by a multicomponent Groebke–Blackburn–Bienaymé reaction is described under sustainable conditions using eucalyptol as green solvent. After determining the optimum conditions for catalysis, a library of 32 compounds with activity on the central nervous system was quickly and efficiently assembled.Keywords
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