H 2 O 2 -Responsive Organochalcogen-Based Probes for 19 F Chemical Shift-Switching MRI

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Abstract
Hydrogen peroxide (H2O2), a key reactive oxygen species, is overexpressed in metabolically dysregulated cells and involved in various disease processes. Herein, we present a class of organochalcogen-based complexes that serve as 19F MRI probes for H2O2 detection by exhibiting large 19F chemical-shift changes upon oxidation. Designed probes based on trifluoromethylselenide (CF3Se-) and trifluoromethyltelluride (CF3Te-) react rapidly with H2O2 under mild reaction conditions. The corresponding 19F chemical-shift changes reach up to 28 and 55 ppm, respectively, under our experimental settings. These substantial shift ranges enable 19F chemical-shift-switching MRI to specifically visualize H2O2-rich regions. Notably, the 19F MRI results of the Se-based analogue demonstrate that a detectable chemical-shift range can be achieved at biologically relevant H2O2 concentrations in a living mouse model of hind limb inflammation. This proof-of-concept study highlights the feasibility of constructing a visual imaging platform using organochalcogen-based 19F MRI probes with large chemical-shift responsiveness.
Funding Information
  • Natural Science Foundation of Xiamen Municipality (3502Z202473035)
  • National Natural Science Foundation of China (82372008)
  • Youth Top Talent of Young Eagle Program of Fujian Province
  • National High Level Hospital Clinical Research Funding (2025-PUMCH-D-003)
  • Fujian Provincial Science and Technology Plan Project (2025Y0002)
  • Nanqiang Top-notch Young Talent Program of XMU

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