Therapeutic Potential of Chamaejasmine: An Important Anticancer Metabolite of Stellera Chamaejasme L.
Open Access
- 1 January 2025
- journal article
- Published by Kare Publishing in Lokman Hekim Health Sciences
- Vol. 5 (1) , 85-90
Abstract
Human illnesses and secondary complications have long been treated with phytomedicine. The majority of herbal drugs were composed of numerous elements of medicinal plants that had therapeutic benefit for human health conditions. Stellera chamaejasme L., contains chamaejasmine as an important phytochemical. Chamaejasmine has potent pain-relieving potential and exerted antitumor activity. Scientific data about chamaejasmine pharmacological properties and therapeutic applications have been collected from a variety of scientific research databases. Additionally, scientific information has been gathered and examined to determine the advantageous function of chamaejasmine. Further, chamaejasmine has also been analyzed for their anticancer potential against cancerous disorders. Present review scientific data described the therapeutic effectiveness of chamaejasmine against cancers. Chamaejasmine scientific data also signified its biological potential in terms of its anti-cancer activity against osteosarcoma, breast cancer, cervical cancer, lung adenocarcinoma, hepatocellular carcinoma, larynx carcinoma, atopic dermatitis and glioblastoma. Present review also described pharmacokinetic parameters of chamaejasmine with its effectiveness on multidrug resistance. The present scientific data pertaining to review studies could be used to investigate the health beneficial aspects of chamaejasmine for their anticancer activity in the future. İnsan hastalıkları ve ikincil komplikasyonlar uzun süredir bitkisel ilaçlarla tedavi edilmektedir. Bitkisel ilaçların çoğunluğu, insan sağlığı koşulları için terapötik fayda sağlayan tıbbi bitkilerin birçok bileşeninden oluşmaktaydı. Stellera chamaejasme L., önemli bir fitokimyasal olan chamaejasmine’i içermektedir. Chamaejasmine güçlü bir ağrı giderici potansiyele sahiptir ve antitümör aktivite göstermektedir. Chamaejasmine’in farmakolojik özellikleri ve terapötik uygulamalarıyla ilgili bilimsel veriler çeşitli bilimsel araştırma veritabanlarından toplanmıştır. Ayrıca, chamaejasmine’in avantajlı işlevini belirlemek amacıyla bilimsel bilgiler toplanmış ve incelenmiştir. Dahası, chamaejasmine’in kanserli hastalıklara karşı antikanser potansiyeli de analiz edilmiştir. Bu derleme çalışması, chamaejasmine’in kanserlere karşı terapötik etkinliğini açıklayan bilimsel verileri sunmaktadır. Chamaejasmine ile ilgili bilimsel veriler, osteosarkom, meme kanseri, rahim ağzı kanseri, akciğer adenokarsinomu, karaciğer hücreli karsinom, gırtlak karsinomu, atopik dermatit ve glioblastoma’ya karşı antikanser aktivitesi açısından biyolojik potansiyelini de ortaya koymaktadır. Bu derleme ayrıca, chamaejasmine’in farmakokinetik parametrelerini ve çoklu ilaç direnci üzerindeki etkinliğini de tanımlamaktadır. Bu derlemeye ilişkin mevcut bilimsel veriler, gelecekte chamaejasmine’in antikanser aktivitesi açısından sağlık açısından faydalı yönlerinin araştırılmasında kullanılabilir.Keywords
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