Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men

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Abstract
Background The aim was to investigate the effect of prolonged endurance exercise on adipose tissue inflammation markers and mitochondrial respiration in young and old men. Methods Young (aged 30 years, n = 7) and old (aged 65 years, n = 7) trained men were exposed to an exercise intervention of 15 consecutive days biking 7-9 hours/day at 63% and 65% of maximal heart rate (young and old, respectively), going from Copenhagen, Denmark to Palermo, Italy. Adipose tissue was sampled from both the gluteal and abdominal depot before and after the intervention. Mitochondrial respiration was measured by high-resolution respirometry and adipose inflammation was assessed by immunohistochemical staining of paraffin embedded sections. Results An increased number of CD163 + macrophages was observed in both the gluteal and abdominal depot (P < 0.01). In addition, an increased mitochondrial respiration was observed in the abdominal adipose tissue from the young group with complex I (CIp) stimulated respiration, complex I + II (CI + IIp) stimulated respiration and the capacity of the electron transport system (ETS)(P < 0.05), and in the old group an increase in CIp and CI + IIp stimulated respiration (P < 0.05) was found. Conclusion Overall, we found a positive effect of prolonged endurance exercise on adipose tissue inflammation markers and mitochondrial respiration in both young and old trained men, and no sign of attenuated function in AT with age.
Funding Information
  • Toms Gruppen A/S
  • Orkla Health, and Radiometer A/S
  • Oda & Hans Svenningsens

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