BIOLOGICAL ACTIVITIES OF U-11100A

Authors:
  • CEC. W. Emmens
    C. W. Emmens
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Abstract
Summary. U-11100A is oestrogenic in vaginal smear tests in rats and mice with a subcutaneous med of ca. 500 μg and 50 to 100 μg respectively. It is also oestrogenic orally and intravaginally and in the tetrazolium reduction test. In all tests, however, the dose-response line turns down again with higher dosage, and full responses were not obtained at the highest dose levels tested. The compound is weakly anti-oestrogenic in both vaginal smear and tetrazolium tests in mice, but exhibits complex interactions with oestradiol, the oestrogen used. U-11100A has an antifertility action when injected on Days 1 to 3 or 4 to 6 of pregnancy in the mouse, 50 μg/day being effective on either schedule. It is felt that this is an expression of its oestrogenicity.