Dynamic Diffuse Optical Tomography for Monitoring Neoadjuvant Chemotherapy in Patients with Breast Cancer

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Abstract
Dynamic diffuse optical tomographic imaging of intrinsic hemodynamic features in tumor-bearing breasts can be used to identify parameters that associate with the degree of pathologic response during 5-month neoadjuvant chemotherapy, as early as 2 weeks after treatment initiation. Purpose To identify dynamic optical imaging features that associate with the degree of pathologic response in patients with breast cancer during neoadjuvant chemotherapy (NAC). Materials and Methods Of 40 patients with breast cancer who participated in a longitudinal study between June 2011 and March 2016, 34 completed the study. There were 13 patients who obtained a pathologic complete response (pCR) and 21 patients who did not obtain a pCR. Imaging data from six subjects were excluded from the study because either the patients dropped out of the study before it was finished or there was an instrumentation malfunction. Two weeks into the treatment regimen, three-dimensional images of both breasts during a breath hold were acquired by using dynamic diffuse optical tomography. Features from the breath-hold traces were used to distinguish between response groups. Receiver operating characteristic (ROC) curves and sensitivity analysis were used to determine the degree of association with 5-month treatment ou...
Funding Information
  • National Science Foundation
  • National Institutes of Health
  • Susan G. Komen for the Cure (KG 111293)
  • Breast Cancer Research Foundation
  • National Institutes of Health (11223309)
  • National Center for Advancing Translational Sciences
  • National Institutes of Health (KL2 TR000081)

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