Ligand-controlled regiodivergence in cobalt-catalyzed hydrosilylation of isoprene
- 23 March 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic Chemistry Frontiers
- Vol. 10 (9) , 2204-2210
Abstract
In this article, we disclose a method for the regiodivergent and stereoselective hydrosilylation of isoprene using an Earth-abundant cobalt catalyst via variation of ligands. With a less sterically hindered bidentate ligand, the reactions proceeded through 4,1-hydrosilylation to afford allylsilanes in excellent regio- and stereoselectivities. By switching to a bulkier ligand, the reactions were efficiently diverted to 2,1-addition products for the first time. This regiodivergent protocol provides a modular approach for the construction of structurally diverse organosilanes with high atom economy and without the formation of stoichiometric byproducts.Keywords
Funding Information
- National Natural Science Foundation of China (22071239)
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