Synthesis and Cytotoxicity Testing of Novel 2‐(3‐Substituted‐6‐chloro‐1,1‐dioxo‐1,4,2‐benzodithiazin‐7‐yl)‐3‐phenyl‐4(3H)‐quinazolinones
Authors:
- 11 July 2008
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 341 (8) , 485-490
Abstract
A new series of thirteen 2-[3-(substituted amino)-6-chloro-1,1-dioxo-1,4,2-benzodithiazin-7-yl]-3-phenyl-4(3H)-quinazolinones 4-16 were prepared in order to evaluate their cytotoxic activity against 12 human cancer cell lines. The bioassay indicated that the quinazolinone derivatives 5, 8–12, 15, and 16 possess cancer-cell growth-inhibitory properties. Compounds 5 and 12 showed a high level of selectivity for certain cell lines. The most active compounds 9, 10, 15, and 16 showed moderate antiproliferative activity and were approximately 4-fold less potent than cisplatin.Keywords
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